Microvascular remodeling and wound healing: A role for pericytes
Brian M. Dulmovits,Ira M. Herman +1 more
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TL;DR: The relationships that pericytes form with the cellular effectors of healing in normal and diabetic environments, including repair following injury and vascular complications of diabetes, such as diabetic macular edema and proliferative diabetic retinopathy are considered.
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About: This article is published in The International Journal of Biochemistry & Cell Biology. The article was published on 01 Nov 2012. and is currently open access. The article focuses on the topics: Pericyte & Angiogenesis.
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Citations
Skin Wound Healing: An Update on the Current Knowledge and Concepts.
TL;DR: Although wound healing mechanisms and specific cell functions in wound repair have been delineated in part, many underlying pathophysiological processes are still unknown and redundancy is high and other cells or mediators can adopt functions or signaling without major complications.
Diabetes and Wound Angiogenesis.
TL;DR: This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis and considers therapeutics that may offer promise to better wound healing outcomes.
Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide
TL;DR: Hydrogen sulfide (H2S), an entry as a gasotransmitter, exerts diverse biological effects through acting on various targeted signaling pathways and is postulated to be a new indicator for endothelial cell inflammation and its associated endothelial dysfunction.
The Role of the Extracellular Matrix Components in Cutaneous Wound Healing
TL;DR: Current known mechanisms, by which extracellular matrix components modulate each stage of the process of soft tissue remodeling after injury, have been discussed.
The role of photobiomodulation on gene expression of cell adhesion molecules in diabetic wounded fibroblasts in vitro
TL;DR: PBM induced a stimulatory effect on various CAMs namely cadherins, integrins, selectins and immunoglobulins, and hence may be used as a complementary therapy in advancing treatment of non-healing diabetic ulcers.
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References
Retinal angiogenesis in development and disease
Ray F. Gariano,Thomas W. Gardner +1 more
TL;DR: The retina has long been regarded as ‘an approachable part of the brain’ for investigating neurosensory processes and cell biologists are now capitalizing on the accessibility to investigate important aspects of developmental angiogenesis, including how it relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor cells.
730
Fibrin structure and wound healing
TL;DR: Fibrin sealants have been investigated as matrices to promote wound healing and are important determinants of angiogenesis and differ in their cell growth stimulation, clotting rate, and fibrin polymerization characteristics.
723
Pericytes and the Pathogenesis of Diabetic Retinopathy
Hans-Peter Hammes,Jihong Lin,Oliver Renner,Moshe Shani,Andrea Lundqvist,Christer Betsholtz,Michael Brownlee,Urban Deutsch +7 more
TL;DR: The pharmacological prevention of acellular capillaries without the rescue of pericyte loss in experimental diabetic retinopathy suggests that the endothelium is the primary therapeutic target.
658
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors.
Magali Saint-Geniez,Arindel S.R. Maharaj,Tony E. Walshe,Budd A. Tucker,Eiichi Sekiyama,Tomoki Kurihara,Diane C. Darland,Michael J. Young,Patricia A. D'Amore +8 more
TL;DR: Results indicate an important role for endogenous VEGF in the maintenance and function of adult retina neuronal cells and indicate that anti-VEGF therapies should be administered with caution.
Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients
TL;DR: The combination of increased concentrations of MMPs with decreased concentrations of TIMP-2 in chronic diabetic foot ulcers compared with healing wounds in normal patients suggests that the increased proteolytic environment contributes to the failure of diabetic wounds to heal.
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