Microsphere Solid‐State Biolasers
TL;DR: In this article, a whispering gallery mode microlaser with thresholds of a few µJ mm-2 and quality factors of up to 3000 was reported, which is compatible with cell growth and resistant to the aqueous environment of cell culture media.
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Abstract: Biolasers obtained from biomaterials are attracting a wealth of interest for their potential as future biosensors with enhanced sensitivity, and advanced cell tracking. Here, miniature biolasers are reported, which are formed by bovine serum albumin (BSA) protein and biosourced polysaccharides derived from land plants such as cellulose and pectin. Using a green processing route aided by simple emulsions, solid-state microspheres with diameters of 15–100 µm are fabricated and utilized as whispering gallery mode lasers with thresholds of a few µJ mm–2 and quality factors of up to 3000. Furthermore, BSA microlasers are found to be compatible with cell growth and resistant to the aqueous environment of cell culture media. This environmentally friendly and biocompatible design shows promise for future implantable biosensing devices opening a path between laser science and medicine.
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Citations
Biological Lasers for Biomedical Applications
TL;DR: The biolaser employs lasing emission rather than regular fluorescence as the sensing signal and therefore has a number of unique advantages that can be explored for broad applications in biosensing, labeling, tracking, contrast agent development, and bioimaging.
134
Biomaterial microlasers implantable in the cornea, skin, and blood
Matjaž Humar,Anja Dobravec,Xiangwei Zhao,Seok Hyun Yun +3 more
- 20 Sep 2017
TL;DR: In this article, the authors demonstrate several types of biocompatible microlasers and their lasing action within biological systems and demonstrate self-assembly to an onion-like radially resonant photonic crystal structure.
81
Detection of acetylcholinesterase and its inhibitors by liquid crystal biosensor based on whispering gallery mode
TL;DR: In this article, a liquid crystal (LC) biosensor based on whispering gallery mode (WGM) lasing is reported and demonstrated for real-time and high-sensitive detection of acetylcholinesterase (AChE) and its inhibitors.
80
Properties and Applications of Random Lasers as Emerging Light Sources and Optical Sensors: A Review
TL;DR: In this article , the current state of the RL properties and applications was reviewed, and the applicability of RLs as light sources and optical sensors has been proved, with tissues as natural scattering materials.
Predicting Protein-Polymer Block Copolymer Self-Assembly from Protein Properties.
Aaron Huang,Justin M. Paloni,Amy Wang,Allie C. Obermeyer,Hursh V. Sureka,Helen Yao,Bradley D. Olsen +6 more
TL;DR: A library of 15 unique protein-b-poly(N-isopropylacrylamide) (PNIPAM) copolymers comprising 11 different proteins was compiled and analyzed and found that bioconjugate ordering can be accurately predicted using only protein molecular weight and percentage of residues contained within β sheets.
22
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