Journal Article10.1146/ANNUREV-BIOENG-010510-103409
Microrobots for Minimally Invasive Medicine
TL;DR: The aim of this review is to provide a comprehensive survey of the technological state of the art in medical microrobots, to explore the potential impact of medical micRORobots and inspire future research in this field.
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Abstract: Microrobots have the potential to revolutionize many aspects of medicine. These untethered, wirelessly controlled and powered devices will make existing therapeutic and diagnostic procedures less invasive and will enable new procedures never before possible. The aim of this review is threefold: first, to provide a comprehensive survey of the technological state of the art in medical microrobots; second, to explore the potential impact of medical microrobots and inspire future research in this field; and third, to provide a collection of valuable information and engineering tools for the design of medical microrobots.
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Citations
Magnetic Helical Microswimmers Functionalized with Lipoplexes for Targeted Gene Delivery
Famin Qiu,Satoshi Fujita,Satoshi Fujita,Rami Mhanna,Li Zhang,Benjamin R. Simona,Bradley J. Nelson +6 more
TL;DR: The successful wirelessly targeted and single‐cell gene delivery to human embryonic kidney cells using ABFs loaded with plasmid DNA (pDNA) in vitro is demonstrated for the first time.
331
Magnetically actuated microrobots as a platform for stem cell transplantation.
Sungwoong Jeon,Sangwon Kim,Shinwon Ha,Seungmin Lee,Eunhee Kim,So Yeun Kim,Sun Hwa Park,Jung Ho Jeon,Sung Won Kim,Cheil Moon,Bradley J. Nelson,Bradley J. Nelson,Jin-young Kim,Seong-Woon Yu,Hongsoo Choi +14 more
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TL;DR: Microrobots used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network and indicated the potential of microrobOTS for the culture and delivery of stem cells.
329
Miniature soft robots — road to the clinic
TL;DR: Soft small robots offer the opportunity to non-invasively access human tissue to perform medical operations and deliver drugs, but challenges in materials design, biocompatibility and function control remain to be overcome for soft robots to reach the clinic.
320
Medical Micro/Nanorobots in Precision Medicine.
TL;DR: The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings, Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.
320
Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow
Yunus Alapan,Ugur Bozuyuk,Pelin Erkoc,Pelin Erkoc,Alp Can Karacakol,Alp Can Karacakol,Metin Sitti,Metin Sitti +7 more
- 20 May 2020
TL;DR: The multifunctional microroller platform described here presents a bioinspired approach toward in vivo controlled propulsion, navigation, and targeted active cargo delivery in the circulatory system.
318
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