MicroRNA in innate immunity and autophagy during mycobacterial infection.
TL;DR: A comprehensive review of the recent literature regarding miRNA profiling in tuberculosis and the roles of miRNAs in modulating innate immune responses and autophagy defenses against mycobacterial infections is presented.
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Abstract: The fine-tuning of innate immune responses is an important aspect of host defenses against mycobacteria MicroRNAs (miRNAs), small non-coding RNAs, play essential roles in regulating multiple biological pathways including innate host defenses against various infections Accumulating evidence shows that many miRNAs regulate the complex interplay between mycobacterial survival strategies and host innate immune pathways Recent studies have contributed to understanding the role of miRNAs, the levels of which can be modulated by mycobacterial infection, in tuning host autophagy to control bacterial survival and innate effector function Despite considerable efforts devoted to miRNA profiling over the past decade, further work is needed to improve the selection of appropriate biomarkers for tuberculosis Understanding the roles and mechanisms of miRNAs in regulating innate immune signaling and autophagy may provide insights into new therapeutic modalities for host-directed anti-mycobacterial therapies Here, we present a comprehensive review of the recent literature regarding miRNA profiling in tuberculosis and the roles of miRNAs in modulating innate immune responses and autophagy defenses against mycobacterial infections
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miRNAs reshape immunity and inflammatory responses in bacterial infection.
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TL;DR: Current knowledge about how microRNAs levels shift during infection with various bacterial pathogens is reviewed, indicating that shifts in microRNA levels in response to different infections could provide a potential bacterial ‘fingerprint’ for achieving accurate diagnosis.
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Sanjaya Kumar Sahu,Manish Kumar,Sohini Chakraborty,Srijon Kaushik Banerjee,Ranjeet Kumar,Pushpa Gupta,Kuladip Jana,Umesh D. Gupta,Zhumur Ghosh,Manikuntala Kundu,Joyoti Basu +10 more
TL;DR: The results attribute crucial roles for the miR-26a/KLF4 and CREB-C/EBPβ signaling pathways in regulating the survival of Mtb in macrophages to the importance of these pathways.
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy
Feng Liu,Jianxia Chen,Peng Wang,Haohao Li,Yilong Zhou,Haipeng Liu,Zhonghua Liu,Ruijuan Zheng,Lin Wang,Hua Yang,Zhenling Cui,Fei Wang,Xiaochen Huang,Jie Wang,Wei Sha,Heping Xiao,Baoxue Ge +16 more
TL;DR: It is shown that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb.
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Mycobacterium tuberculosis -induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells
Marilena P. Etna,Alessandro Sinigaglia,Angela Grassi,Elena Giacomini,Alessandra Romagnoli,Manuela Pardini,Martina Severa,Melania Cruciani,Fabiana Rizzo,Eleni Anastasiadou,Barbara Di Camillo,Luisa Barzon,Gian Maria Fimia,Riccardo Manganelli,Eliana M. Coccia +14 more
TL;DR: How Mtb can manipulate cellular miRNA expression to regulate Atg3 for its own survival is suggested, and the importance to develop novel therapeutic strategies against tuberculosis that would boost autophagy is highlighted.
Autophagy and Its Interaction With Intracellular Bacterial Pathogens
TL;DR: This review aims to discuss recent findings on the role of autophagy as a cellular response to intracellular bacterial pathogens such as, Streptococcus pyogenes, Mycobacterium tuberculosis, Shigella flexneri, Salmonella typhimurium, Listeria monocytogenes and Legionella pneumophila, how the autophagic machinery senses these bacteria directly or indirectly.
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