Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development.

TL;DR: The study revealed that "Cardiovascular Diseases" and "Nutritional and Metabolic Diseases" were highly relevant as level 1 Medical Subject Headings descriptors in COVID-19 comorbidity research, highlighting the importance of both glucose and iron metabolism disorders in COVID-19 research.

TL;DR: In this paper , the authors used SARS-CoV-2 peptide microarrays to assess the differences between 44 volunteers inoculated with the inactivated virus vaccine BBIBP-CorV and 61 patients who were infected with SARS CoV-II, and found that the specific antibody responses against S15, S64, and S104 peptides were stronger in vaccinators than in infected persons.

TL;DR: In this article, a two-stage particle separation channel using ultrasound is proposed, where two different sound pressure regions are used to achieve the separation of particles with positive acoustic contrast factors.

TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.

TL;DR: Dipeptidyl peptidase 4 (DPP4; also known as CD26) is identified as a functional receptor for hCoV-EMC and will contribute critically to the understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.

TL;DR: First, a simple method for constructing E1-substituted adenovirus vectors carrying recombinant genes in place of all of the viral genes is demonstrated, so-called gutless adenOVirus vectors.

TL;DR: It is reported here that, in mice, the low toxicity of MPLA's adjuvant function is associated with a bias toward TRIF signaling, which is likely caused by the active suppression, rather than passive loss, of proinflammatory activity of this LPS derivative.