Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development.

TL;DR: Previously available literature data about coronavirus vaccine designing may play crucial role in development of rapid vaccine against COVID-19, and possible target sites for designing of vaccine against SARS-CoV-2 virus are suggested.

TL;DR: In this paper, a machine-learning algorithm capable of identifying whether a given patient (actually infected or suspected to be infected) is more likely to survive than to die, or vice-versa, is presented.

TL;DR: This review focuses on the challenges and prospects of vaccine development against CO VID‐19 and highlights seriousness, bottlenecks in vaccine development, possible vaccine candidates, different vaccine strategies, safety evaluation issues, and vaccine production process pertaining to COVID‐19 based on the knowledge acquired on SARS and MERS vaccine development in the past.

TL;DR: The COVID-19 outbreak caused by a novel coronavirus was declared as a global pandemic by WHO more than five months ago, and we are still experiencing a state of global emergency as discussed by the authors.

TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.

TL;DR: Dipeptidyl peptidase 4 (DPP4; also known as CD26) is identified as a functional receptor for hCoV-EMC and will contribute critically to the understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.

TL;DR: First, a simple method for constructing E1-substituted adenovirus vectors carrying recombinant genes in place of all of the viral genes is demonstrated, so-called gutless adenOVirus vectors.

TL;DR: It is reported here that, in mice, the low toxicity of MPLA's adjuvant function is associated with a bias toward TRIF signaling, which is likely caused by the active suppression, rather than passive loss, of proinflammatory activity of this LPS derivative.