Journal Article10.1002/ADMA.200501129
Microfluidics for Processing Surfaces and Miniaturizing Biological Assays
TL;DR: This review is an account of the efforts to develop a versatile and flexible microfluidic technology for surface‐processing applications and miniaturizing biological assays and addresses some of the major challenges for confining chemical and biochemical processes on surfaces.
read more
Abstract: This review is an account of our efforts to develop a versatile and flexible microfluidic technology for surface-processing applications and miniaturizing biological assays. The review is presented in the context of current trends in microfluidic technology and addresses some of the major challenges for confining chemical and biochemical processes on surfaces: the sealing of a microchannel with a surface, the world-to-chip interface, the displacement of liquids in small conduits, the sequential delivery of multiple solutions, the accurate patterning of surfaces, the coincident detection of various analytes, and the detection of analytes in a small and dilute sample. Our solutions to these problems include the use of reversible sealing, capillary phenomena for powering and controlling liquid transport, and non-contact microfluidics for spotting and drawing (on surfaces) with flow conditions. These solutions offer many advantages over conventional techniques for handling minute amounts of liquids and may find applications in lithography, biopatterning (e.g., the patterning of biomolecules), diagnostics, drug discovery, and also cellular assays.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Multiphase microfluidics: from flow characteristics to chemical and materials synthesis
Axel Günther,Klavs F. Jensen +1 more
TL;DR: Transport characteristics of pressure-driven, multiphase flows through microchannel networks tens of nanometres to several hundred of micrometres wide are reviewed with emphasis on conditions resulting in enhanced mixing and reduced axial dispersion.
1K
SU-8: a photoresist for high-aspect-ratio and 3D submicron lithography
A. del Campo,Christian Greiner +1 more
TL;DR: The SU-8 photoresist has become the favourite photoreist for high-aspect-ratio (HAR) and three-dimensional (3D) lithographic patterning due to its excellent coating, planarization and processing properties as well as its mechanical and chemical stability as mentioned in this paper.
912
Microfluidic Chips for Point‐of‐Care Immunodiagnostics
TL;DR: An overview on microfluidic devices that may become the next generation of point-of-care (POC) diagnostics is provided, and gaps and opportunities in medical diagnostics are described and howmicrofluidics can address these gaps using the example of immunodiagnostics.
506
Fabrication approaches for generating complex micro- and nanopatterns on polymeric surfaces.
TL;DR: This research presents a meta-lithography program that automates and automates the very labor-intensive and therefore time-heavy and expensive and expensive process of writing and material deposition for two-Photon Lithography.
490
Capillary pumps for autonomous capillary systems
TL;DR: Capillary pumps having different hydrodynamic properties can be connected to program a sequence of slow and fast flow rates in a CS to obtain a reliable filling behaviour and to minimize the risk of entrapping air.
389
References
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
8.9K
Chaotic Mixer for Microchannels
Abraham D. Stroock,Stephan K. W. Dertinger,Armand Ajdari,Igor Mezic,Howard A. Stone,George M. Whitesides +5 more
TL;DR: This work presents a passive method for mixing streams of steady pressure-driven flows in microchannels at low Reynolds number, and uses bas-relief structures on the floor of the channel that are easily fabricated with commonly used methods of planar lithography.
3.6K
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
TL;DR: The data suggest that the C-reactive protein level is a stronger predictor of cardiovascular events than the LDL cholesterol level and that it adds prognostic information to that conveyed by the Framingham risk score.
3.5K
High-Resolution Inkjet Printing of All-Polymer Transistor Circuits
Henning Sirringhaus,Takeo Kawase,Richard H. Friend,Tatsuya Shimoda,M. Inbasekaran,Weishi Wu,E. P. Woo +6 more
TL;DR: It is shown that the use of substrate surface energy patterning to direct the flow of water-based conducting polymer inkjet droplets enables high-resolution definition of practical channel lengths of 5 micrometers, and high mobilities were achieved.
Formation of monolayer films by the spontaneous assembly of organic thiols from solution onto gold
Colin D. Bain,E. Barry Troughton,Yu-Tai Tao,Joseph Evall,George M. Whitesides,Ralph G. Nuzzo +5 more
TL;DR: In this paper, the authors used contact angles and optical ellipsometry to study the kinetics of adsorption of monolayer films and to examine the experimental conditions necessary for the formation of high-quality films.