Journal Article10.1039/C2CE06167H
Microfluidic approach to polymorph screening through antisolvent crystallization
TL;DR: A microfluidic platform comprised of 48 wells to screen for polymorphs of active pharmaceutical ingredients (API) through antisolvent crystallization was presented in this article. But, the platform is not suitable for solubility analysis.
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Abstract: Here we present a microfluidic platform comprised of 48 wells to screen for polymorphs of active pharmaceutical ingredients (API) through antisolvent crystallization. API solutions and anti-solvents are precisely metered in various volumetric ratios (range from 50 : 10 to 10 : 50), and mixed via diffusive mixing on-chip. Optical microscopy and Raman spectroscopy were used to analyze the resultant solids. The small volumes (37 nL) and the ability to screen a wide range of supersaturations through diffusive mixing make this platform especially useful for solid form development at discovery and early development stages in pharmaceutical industry. To validate this microfluidic approach, we conducted on-chip antisolvent crystallization using indomethacin. Solvent choice, supersaturation level, and antisolvent-to-solution ratio were found to affect the resulting crystal form of the solids prepared on chip. We modelled the representative time-dependent concentration profiles during the mixing of the antisolvent and API solutions. Combining this analysis with solubility data yielded spatiotemporal supersaturation profiles, which we correlated with solid formation as observed experimentally.
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Citations
Screening for new pharmaceutical solid forms using mechanochemistry: A practical guide.
Dritan Hasa,William Jones +1 more
TL;DR: This review focuses on particular practical aspects of mechanochemistry in order to allow full optimisation of the approach in searches for new solid forms including polymorphs, salts and cocrystals as well as their solvated/hydrated analogues.
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A multiplexed microfluidic platform for rapid antibiotic susceptibility testing.
Ritika Mohan,Arnab Mukherjee,Selami E. Sevgen,Chotitath Sanpitakseree,Jaebum Lee,Charles M. Schroeder,Paul J. A. Kenis +6 more
TL;DR: A microfluidic platform that relies on fluorescence detection of bacteria that express green fluorescent protein for highly sensitive and rapid antibiotic susceptibility testing and has the potential to provide rapid and precise guidance in clinical therapies by identifying the antibiograms of pathogens.
144
Recent progress of structural study of polymorphic pharmaceutical drugs.
TL;DR: This review considers advances in the understanding of active pharmaceutical ingredient polymorphism since around 2010 mainly from a structural view point, with a focus on twelve model drugs, finding new polymorphs of most of these drugs have been identified.
83
Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine
TL;DR: In this paper, a supercritical CO2-antisolvent crystallization process in combination with certain molecular additives allows control of the polymorphic outcome of carbamazepine (CBZ).
64
Characteristics of indomethacin-saccharin (IMC-SAC) co-crystals prepared by an anti-solvent crystallization process.
TL;DR: The anti-solvent approach can be considered as a competitive route for producing pharmaceutical co-crystal powders with acceptable properties and was explained with two aspects: phase solubility diagram and solution complexation concept.
54
References
Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices.
TL;DR: This paper describes the compatibility of poly(dimethylsiloxane) (PDMS) with organic solvents; this compatibility is important in considering the potential of PDMS-based microfluidic devices in a number of applications, including that of microreactors for organic reactions.
2.5K
Microfluidic Large Scale Integration
Stephen R. Quake
- 01 Mar 2003
TL;DR: High-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers are developed to construct the microfluidity analog of a comparator array and a microfluidsic memory storage device whose behavior resembles random-access memory.
2.3K
Microfluidic large scale integration
TL;DR: The fluidic multiplexor as discussed by the authors is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs.
2.2K
•Book
Polymorphism in Pharmaceutical Solids
Harry G. Brittain
- 03 Mar 1999
TL;DR: Brittain et al. as mentioned in this paper applied the phase rule to the characterisation of polymorphic and solvatomorphic systems, and proposed a computational method to predict polymorphism.
1.8K