Peer Review
Microemulsion –A Multidimensional Formulation
TL;DR: In this article , the authors reviewed the structure of microemulsion and their components like oil, surfactant, cosurfactant and water and discussed the multiple importance of micromulsion.
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Abstract: ---------------------------------------------------------------------------------------------------------------------------------------ABSTRACT The trend of developing new formulation for drug delivery is growing worldwide due to introduction of new drugs as well as to solve problems of existing drugs. However, the formulation for lipophilic drugs needs much concern due to low aqueous solubility and bioavailability issues in oral route . Microemulsion plays an important role in drug delivery due to its ability to reduce interfacial tension between oil and water to a large extent as well its high solubilization ability. This paper reviews the structure of microemulsion and their components like oil, surfactant, cosurfactant and water. HLB value was considered for the selection criteria of surfactant that is the essential component of microemulsion. The method os preparation as well as characterization parameters were also discussed This review also discussed the multiple importance of micromulsion. The microemulsion formulation can be used for the different route of drug administration like parenetaral, oral etc.. This paper also described the application of microemulsion in cosmetic as well as washing applications.
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References
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more
TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.
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Development and bioavailability assessment of ramipril nanoemulsion formulation.
TL;DR: The present study revealed that ramipril nanoemulsion could be used as a liquid formulation for pediatric and geriatric patients and can be formulated as self-nanoemulsifying drug delivery system (SNEDDS) as a unit dosage form.
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Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects
TL;DR: This review highlights the state-of-the-art in pharmaceutical microemulsions with emphasis on self-emulsifying systems, from both a physical and biopharmaceutical perspective, primarily focused on their potential for oral drug delivery and intestinal absorption improvement.
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Microemulsions as transdermal drug delivery vehicles.
Anna Kogan,Nissim Garti +1 more
TL;DR: Microemulsions were found as an effective vehicle of the solubilization of certain drugs and as protecting medium for the entrapped of drugs from degradation, hydrolysis, and oxidation.
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Oral lipid-based formulations
TL;DR: This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives.
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