Patent
Microcapsule-based vaccine
Ma Guanghui,Wei Wei,Xiaobo Xi,Tong Ye,Na Xiangming,Qing Shuang +5 more
- 27 Feb 2020
TL;DR: In this paper, a vaccine consisting of an antigen and a biodegradable polymer blend matrix is presented, which contains a hydrophobic polymer and an amphiphilic block copolymer.
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Abstract: The invention relates to a vaccine comprising an antigen and a biodegradable polymer blend matrix. The polymer blend contains a hydrophobic polymer and an amphiphilic block copolymer. The vaccine exists in a microcapsule mode; a multi-cavity structure is contained in the microcapsule; and the average particle size of the microcapsule is preferably 10 to 100 micrometers, preferably 30 to 60 micrometers. The microcapsule is prepared by the following method: preparing open-pore microspheres from a polymer blend; mixing the open-pore microspheres with an antigen-containing solution; and then sealing the open-pore microspheres loaded with an antigen solution to form the sealed microcapsule loaded with the antigen.
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Patent
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Joseph A. Vetro,Sam D. Sanderson +1 more
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