Journal Article10.1021/JP982568O
Micellar Structure of an Ethylene Oxide−Propylene Oxide Block Copolymer: A Small-Angle Neutron Scattering Study
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TL;DR: In this paper, small-angle neutron scattering (SANS) was used to examine micellar solutions of a highly hydrophilic ethylene oxide−propylene oxide triblock copolymer, pluronic F88, in aqueous solution.
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Abstract: Micellar solutions of a highly hydrophilic ethylene oxide−propylene oxide triblock copolymer, pluronic F88 (EO103PO39EO103), in aqueous solution are examined by small-angle neutron scattering (SANS) at different concentrations and temperatures and in the presence of different salts. At temperature less than 30 °C, F88 solution in water (5 wt %) showed unimers which are fully dissolved Gaussian chains. The unimer-to-micelle transition takes place when the temperature or concentration is increased. Added neutral salt favors micellization of the copolymer at lower concentration/temperature. At temperature close to ambient, block copolymer forms micelles that consist of a central core, presumably dominated by the propylene oxide blocks, surrounded by a corona of highly hydrated ethylene oxide subchains. SANS analysis shows that the size of hydrophobic core increases as a part of PEO adjacent to the PPO core loses water with increasing temperature or salt (KCl) concentration. The micellar volume fraction incre...
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Citations
Poly(ethylene oxide)–poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs
TL;DR: The present review provides a concise description of the most important applications of PEO-PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs.
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•Journal Article
Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations.
José Juan Escobar-Chávez,Miriam López-Cervantes,Aarti Naik,Yogeshvar N. Kalia,David Quintanar-Guerrero,Adriana Ganem-Quintanar +5 more
TL;DR: Of these systems, Pluronic F-127 (PF-127) provides the pharmacist with an excellent drug delivery system for a number of routes of administration and is compatible with many different substances.
In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate
TL;DR: In vivo study showed that the ocular bioavailability of TM, measured in albino rabbits, increased by 2.5 and 2.4 fold for 25% PF127 gel formulation and 15%PF127 containing 3% methylcellulose, respectively, compared with 0.5% TM aqueous solution.
349
Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution
TL;DR: In this paper, the micellization of an EO-propylene oxide (PEO-PPO-PEO) symmetrical triblock copolymer (Pluronic®) F127 (EO 99 PO 65 EO 99, mol. wt. PPO=1750, %PEO=70) in aqueous solution in the presence of various additives (i.e., sodium chloride, urea and sodium dodecyl sulfate (SDS)) is examined by cloud point, surface tension, dye spectral change, sound velocity, viscos
283
Dual-drug delivery system based on hydrogel/micelle composites
TL;DR: A dual-drug delivery system (DDDS) of hydrogel/polypeptide micelle composites was constructed from aspirin (Asp) dispersed poly(vinyl alcohol) (PVA) or Chitosan (CS)/PVA hydrogels and doxorubicin (DOX) loaded poly(L-glutamic acid)-b-poly(propylene oxide) (GPG) micelles.
281
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