Mice are not susceptible to hepatitis E virus infection.
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TL;DR: To determine whether or not mice are susceptible to hepatitis E virus (HEV) infection, C57BL/6 mice were experimentally infected with genotypes 1, 3 and 4 HEV by intravenous injection and none of the serum or stool samples was positive for virus replication, demonstrating that C 57BL/ 6 mice were not susceptible to HEV.
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Abstract: To determine whether or not mice are susceptible to hepatitis E virus (HEV) infection, C57BL/6 mice were experimentally infected with genotypes 1, 3 and 4 HEV by intravenous injection. Serum and stool samples were collected and used to detect HEV RNA and anti-HEV antibodies by RT-PCR and ELISA. The virus infection was monitored up to two months after inoculation; however, none of the serum or stool samples was positive for virus replication, demonstrating that C57BL/6 mice were not susceptible to HEV.
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Citations
Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR
TL;DR: A nested broad-spectrum RT-PCR protocol was developed capable of detecting different HEV types including those derived from wild boar and chicken and its suitability to serve in a laboratory rat animal model for human hepatitis E is assessed.
352
Zoonotic Hepatitis E Virus: Classification, Animal Reservoirs and Transmission Routes.
TL;DR: The aim of this review is to present the recent discoveries of animal HEVs and their classification within the Hepeviridae family, their zoonotic and species barrier crossing potential, and possible use as models to study hepatitis E pathogenesis.
238
Susceptibility of laboratory rats against genotypes 1, 3, 4, and rat hepatitis E viruses.
Tian-Cheng Li,Sayaka Yoshizaki,Yasushi Ami,Yuriko Suzaki,Shumpei P. Yasuda,Kumiko Yoshimatsu,Jiro Arikawa,Naokazu Takeda,Takaji Wakita +8 more
TL;DR: It is demonstrated that rats are susceptible to rat HEV but not to G1, G3, and G4 HEV, and it is confirmed that the nude rats were useful for obtaining a large amount of ratHEV and that the rat HeV was transmitted by the fecal-oral route.
49
Antiviral strategies for hepatitis E virus
Yannick Debing,Johan Neyts +1 more
TL;DR: There is an urgent need for better antiviral treatments that are efficacious and safe, also during pregnancy, and the available assay systems and potential molecular targets for the development of inhibitors of HEV replication are reviewed.
47
Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area
Hongwei Fu,Lingjun Li,Yonghong Zhu,Ling Wang,Jiabao Geng,Yibin Chang,Cheng Xue,Gang Du,Yaning Li,Hui Zhuang +9 more
TL;DR: The human HEV strain (CHN-XJ-HE29) shared 100% nucleotide identity with the swine HEV strains, both of which were collected from the same district; this indicates the possibility of HEV transmission from swine to humans in an endemic area of Xinjiang, China.
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A novel virus in swine is closely related to the human hepatitis E virus
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Xiang-Jin Meng,Patrick G. Halbur,Max Shapiro,Sugantha Govindarajan,J. Bruna,Isa K. Mushahwar,Robert H. Purcell,Suzanne U. Emerson +7 more
TL;DR: The results suggested that swine HEV may infect humans, and in a reciprocal experiment, specific-pathogen-free pigs were experimentally infected with the US-2 strain of human HEV that is genetically similar to swineHEV.
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