1. What is the favored method in Aslam’s procedure?
Sheldon’s EF is favored in Aslam’s procedure due to a staggering 97 % yield using purely stoichiometric amounts (1.0 equiv) of phosphonium salt and BuLi.
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2. What is the reaction of benzaldehyde and styrene?
In their case, by simply mixing 1 and 2 e in 2Me-THF and heating at reflux, >98 % isolated yield of methylene-dioxystyrene 3 e was obtained on a multigram scale (~3 g, 20 mmol), without formation of halide salts (Scheme 6).
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3. What is the molar ratio of a ketone?
The vinylation of ketones required to increase the molar ratio 1/ketone up to 3 in order to achieve 100 % conversion and 100 % selectivity toward the desired products (Scheme 8).
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4. What is the reaction order of benzaldehyde 2 a?
Reactivity followed the order 2 d ! 2 g<2 h<2 e<2 f<2 a< 2 c<2 b. Aromatic aldehydes with electron-withdrawing groups (EWGs) reacted faster than ones with electron-donating groups (EDGs) and aliphatic aldehydes required longer reaction times.
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![Table 1. Calculated green metrics for the conversion of 2e into 3e.[a]](/figures/table-1-calculated-green-metrics-for-the-conversion-of-2e-ya41uuf0.webp)
![Figure 3. 1H NMR spectra of [Ph3PCH3][CH3OCO2] 1 in the P-CH3 region acquired in CDCl3 at 10 min time intervals.](/figures/figure-3-1h-nmr-spectra-of-ph3pch3-ch3oco2-1-in-the-p-ch3-2knc6455.webp)
