Patent
Methods and compositions for treatment of bcr-abl associated leukemias and other cell proliferative disorders
Joseph Schlessinger,Mikhail L. Gishizky,Ann Marie Pendergast,Harald App +3 more
- 28 Sep 1994
11
TL;DR: In this article, the authors proposed a method for the prevention and treatment of cell proliferative disorders where a protein tyrosine kinase/adaptor protein complexes are involved and the uses of these complexes for the identification of agents capable of decreasing or inhibiting the interaction between the members of such complexes.
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Abstract: The present invention relates to compositions and methods for the prevention and treatment of cell proliferative disorders wherein a protein tyrosine kinase or protein tyrosine phosphatase capable of complexing with a member of the SH2- and/or SH3 domain-containing family of adaptor proteins is involved. This invention is based, in part, on the surprising discovery that the adaptor protein, GRB-2, binds the intracellular BCR-ABL tyrosine kinase product in vivo and is necessary for the activation of the oncogenic potential of the BCR/ABL product. The present invention further relates to protein tyrosine kinase/adaptor protein complexes and the uses of these complexes for the identification of agents capable of decreasing or inhibiting the interaction between the members of such complexes.
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Citations
Patent
Antioxidant enhancement of therapy for hyperproliferative conditions
Rebecca Chinery,R. Daniel Beauchamp,Robert J. Coffey,Russell M. Medford,Brian Wadsinski +4 more
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TL;DR: In this paper, the authors proposed a method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineplastic drug to a host exhibiting abnormal cell proliferation in combination with an effective cytotoxicity-increasing amount of an antioxidant.
201
Patent
Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth
Ralph B. Arlinghaus,Jiaxin Liu,Gabriel Lopez-Berestein,Dai Lu,Yun Wu +4 more
- 16 Feb 1996
TL;DR: In this paper, compositions comprising or encoding one or more peptides that inhibit the Bcr-Abl oncoprotein and that bind to molecules involved in BcrAbl function are disclosed.
28
Patent
Semiactive suspension awning damp control algorithm for vehicle speed and road inductive automobile
Gang Wang,Zhiguo Zhao,Zhuoping Yu,Zechang Sun +3 more
- 22 Mar 2006
TL;DR: In this paper, the authors proposed a semi-active suspension awning damp control algorithm for vehicle speed and road inducing automobile, which includes the following steps: 1. determining the off-line simulation result of awnings damp control coefficient under fixed vehicle speed, and 2. estimating the road unevenness grade with the road detector and based on the vertical acceleration of the spring carried mass and the vehicle speed.
17
Patent
Abl-interactor protein
Ann Marie Pendergast,Zonghan Dai +1 more
- 25 Oct 1996
TL;DR: The present paper relates to a protein that interacts with the cAbl protein tyrosine kinase and to a nucleic acid sequence encoding the same as mentioned in this paper, and also relates to complexes of the protein of the invention and cABL and to the use of such complexes in the identification of therapeutic and diagnostic agents.
10
Patent
Adaptor protein FRS2 and related products and methods
Haruhiko Kouhara,T Spivak-Kroizman,Irit Lax,Joseph Schlessinger +3 more
- 01 Dec 1997
TL;DR: In this article, a newly identified adaptor protein FRS2 and related products and methods are discussed. And methods for diagnosing abnormal conditions in an organism with FRS 2 related molecules or compounds are presented.
5
References
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
E. Lowenstein,Roger J. Daly,A. Batzer,W. Li,B. Margolis,Richard L. Lammers,Axel Ullrich,Edward Y. Skolnik,Dafna Bar-Sagi,Joseph Schlessinger +9 more
TL;DR: Results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling.
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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
Sean E. Egan,Barton W. Giddings,Mary W. Brooks,László Buday,Andrew M. Sizeland,Robert A. Weinberg +5 more
TL;DR: A pathway by which tyrosine kinases act through Ras to control cell growth and differentiation is defined.
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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
TL;DR: In rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos, which appears to link tyrosine kinases to a Ras-GNRP in mammalian cells.
1K