Patent
Methods and compositions for selecting siRNA of improved functionality
Anastasia Khvorova,Angela Reynolds,Devin Leake,William Marshall,Steven Read,Stephen Scaringe +5 more
- 12 May 2004
335
TL;DR: In this paper, a rational design of siRNAs for gene silencing is described, including those directed to the nucleotide sequences for HAO1, and methods for silencing genes.
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Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
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Citations
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Method, system, and computer-readable medium for providing a scalable bio-informatics sequence search on cloud
shri. Shyam Kumar Doddavula,Madhavi Rani,Anirban Ghosh,Akansha Jain,Santonu Sarkar,Mudit Kaushik,Harsh Vachhani +6 more
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A. Jimenez,Angela Sesto,José P. Román,Irene Gascón,Gonzalez De Buitrago Gonzalo,Jimenez Maria Concepcion +5 more
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Querbes William,Fitzgerald Kevin,Bettencourt Brian,Abigail Liebow,David Erbe +4 more
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TL;DR: Combination products comprising an antisense oligonucleotide against the gene encoding a mammalian R- reductase R2 protein and one or more immunotherapeutic agents, such as cytokines, non-cytokine adjuvants, monoclonal antibodies and cancer vaccines are also provided in this article.
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.
Marianne Abifadel,Mathilde Varret,Jean-Pierre Rabès,Delphine Allard,Khadija Ouguerram,Martine Devillers,Corinne Cruaud,Suzanne Benjannet,Louise Wickham,D. Erlich,Aurélie Derré,Ludovic Villéger,Michel Farnier,Isabel Beucler,Eric Bruckert,Jean Chambaz,Bernard Chanu,Jean-Michel Lecerf,Gérald Luc,Philippe Moulin,Jean Weissenbach,Annick Prat,Michel Krempf,Claudine Junien,Nabil G. Seidah,Catherine Boileau +25 more
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