Methodological challenges when comparing demographic and clinical characteristics of international observational registries.
Suzanne M M Verstappen,Johan Askling,Niklas Berglind,Stefan Franzén,Thomas Frisell,Christopher Garwood,Jeff Greenberg,Marie Holmqvist,Laura Horne,Kathy Lampl,Kaleb Michaud,Fredrik Nyberg,Dimitrios A. Pappas,George W. Reed,Deborah P M Symmons,Eiichi Tanaka,Trung N. Tran,Hisashi Yamanaka,Meilien Ho +18 more
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TL;DR: Comparisons of data from different registries can be helpful in understanding variations in many aspects of rheumatoid arthritis (RA) and the comparability of demographic, clinical, and comorbidity data from 5 international RA registries is improved.
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Abstract: OBJECTIVE: Comparisons of data from different registries can be helpful in understanding variations in many aspects of rheumatoid arthritis (RA). The study aim was to assess and improve the comparability of demographic, clinical, and comorbidity data from 5 international RA registries. METHODS: Using predefined definitions, 2 subsets of patients (main cohort and sub-cohort) from 5 international observational registries (CORRONA, SRR, NOAR, IORRA, and CORRONA International) were evaluated and compared. Patients with RA aged >18 years, and present in or recruited to the registry from January 1, 2000, were included in the main cohort. Patients from the main cohort with positive rheumatoid factor and/or erosive RA who had received ?1 sDMARD, and switched to or added another DMARD, were included in the sub-cohort at time of treatment switch. RESULTS: Age and gender distributions were fairly similar across the registries. The percentage of patients with high DAS28 score varied between main cohorts (17.5% IORRA, 18.9% CORRONA, 24.7% NOAR, 27.7% CORRONA International, and 36.8% SRR), with IORRA, CORRONA, and CORRONA International including more prevalent cases of RA; the differences were smaller for the sub-cohort. Prevalence of comorbidities varied across registries (e.g., coronary artery disease ranging from 1.5% in IORRA to 7.9% in SRR), partly due to the way comorbidity data was captured and general cultural differences; the pattern was similar for the sub-cohorts. CONCLUSION: Despite different inclusion criteria for the individual RA registries, it is possible to improve the comparability and interpretability of differences across RA registries by applying well-defined cohort definitions. This article is protected by copyright. All rights reserved.
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Citations
Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis.
Shangyi Jin,Mengtao Li,Yongfei Fang,Qin Li,Ju Liu,Xinwang Duan,Yi Liu,R Wu,Xiaofei Shi,Yongfu Wang,Zhenyu Jiang,Yanhong Wang,Chen Yu,Qian Wang,Xinping Tian,Yan Zhao,Xiaofeng Zeng +16 more
TL;DR: Patients with rheumatoid arthritis in China have similar prevalence of comorbidities with other Asian countries, and methotrexate (MTX) may protect RA patients from several major comorebidities, supporting its central role in the management of rheumatic arthritis.
Remission rate and predictors of remission in patients with rheumatoid arthritis under treat-to-target strategy in real-world studies: a systematic review and meta-analysis
Chen Yu,Shangyi Jin,Yanhong Wang,Nan Jiang,Chanyuan Wu,Qian Wang,Xinping Tian,Mengtao Li,Xiaofeng Zeng +8 more
TL;DR: Remission was a reachable target in real-world studies, while attention should also be paid to achieve sustained remission, while initial use of corticosteroids was negative predictors of remission.
73
The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable
David P. Nickerson,Koray Atalag,Bernard de Bono,Jörg Geiger,Carole Goble,Susanne Hollmann,Joachim Lonien,Wolfgang Müller,Babette Regierer,Natalie J. Stanford,Martin Golebiewski,Peter Hunter +11 more
TL;DR: The standards, software tooling, repositories and infrastructures that support this work are explored, and what makes them vital to realizing the Human Physiome are detailed.
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Can rheumatoid arthritis (RA) registries provide contextual safety data for modern RA clinical trials? The case for mortality and cardiovascular disease
Kaleb Michaud,Niklas Berglind,Stefan Franzén,Thomas Frisell,Christopher Garwood,Jeff Greenberg,Meilien Ho,Marie Holmqvist,Laura Horne,Eisuke Inoue,Fredrik Nyberg,Fredrik Nyberg,Dimitrios A Pappas,George W. Reed,Deborah P M Symmons,Eiichi Tanaka,Trung N. Tran,Suzanne M M Verstappen,Eveline Wesby-van Swaay,Hisashi Yamanaka,Johan Askling +20 more
TL;DR: This coordinated approach to contextualising RA RCT safety data demonstrated reasonable differences and consistency in rates for mortality and CVD across registries, and comparable RCT rates, and may serve as a model method to supplement clinical trial analyses for drug development programmes.
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Treatment patterns and achievement of the treat-to-target goals in a real-life rheumatoid arthritis patient cohort: data from 1317 patients.
Konstantinos Thomas,Argiro Lazarini,Evripidis Kaltsonoudis,Alexandros A. Drosos,Ioannis Papalopoulos,Prodromos Sidiropoulos,P. Tsatsani,S. Gazi,L. Pantazi,Kyriaki A. Boki,Pelagia Katsimbri,Dimitrios T. Boumpas,Kalliopi Fragkiadaki,Maria G Tektonidou,Petros P. Sfikakis,Konstantina Karagianni,Lazaros I. Sakkas,Eleftheria P. Grika,P. G. Vlachoyiannopoulos,Gerasimos Evangelatos,Alexios Iliopoulos,Theodoros Dimitroulas,Alexandros Garyfallos,Konstantinos Melissaropoulos,Panagiotis Georgiou,M. Areti,C. Georganas,P. Vounotrypidis,George D. Kitas,Dimitrios Vassilopoulos +29 more
TL;DR: In a real-life RA cohort, during 1 year of follow-up, 43% of patients do not reach treatment targets while only ~20% of those with active RA started or switched their bDMARDs.
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Differences in risk factors, atherosclerosis and cardiovascular disease between ethnic groups in Canada: the study of health assessment and risk in ethnic groups (SHARE).
Sonia S. Anand,Salim Yusuf,Vuksan,Sudarshan Devanesen,Teo Kk,Patricia A Montague,Linda E. Kelemen,Yi C,Eva Lonn,Hertzel C. Gerstein,Robert A. Hegele +10 more
TL;DR: Although there are differences in conventional and novel risk factors between ethnic groups, this variation and the degree of atherosclerosis only partly explains the higher rates of cardiovascular disease among South Asians compared with Europeans and Chinese.
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