Patent
Method for synthesis of 1,8-diazaspiro [4,5] decane-3-hydroxy-1-benzyl-8-carboxylic acid tert-butyl ester
Gao Feng,Zeng Sailan +1 more
- 16 Dec 2015
1
TL;DR: In this paper, a method for synthesis of the bicyclic compound 1,8-diazaspiro [4,5] decane-3-hydroxy-1-benzyl-8-carboxylic acid tert-butyl ester is presented.
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Abstract: The invention discloses a method for synthesis of the bicyclic compound 1,8-diazaspiro [4,5] decane-3-hydroxy-1-benzyl-8-carboxylic acid tert-butyl ester. The raw material N-Boc-4-piperidone easy to obtain is adopted, and the 1,8-diazaspiro [4,5] decane-3-hydroxy-1-benzyl-8-carboxylic acid tert-butyl ester is obtained through dehydration condensation reaction, allyl Grignard addition reaction, epoxidation reaction and proton abstraction ring-closing reaction which are conducted continuously.
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Citations
Patent
Preparation method of Boc-1-(benzyl)-3-iodo-[1,8]diazaspiro[4,5]heptane-8-carboxylate
Liu Shuang,Wang Mi,Yang Yunlong,Mao Jing,Chen Dongzhi,Wang Yongsheng,Pang Zhou,Zhang Hongwei,Yu Lingbo,Ma Rujian +9 more
- 30 Aug 2019
TL;DR: In this paper, a synthesis method of tert-butoxycarbonyl-1-(benzyl)-3-iodo-[1,8]diazaspiro[4,5]heptane-8-carboxylate, and mainly solve the technical problem that no synthesis method suitablefor industrialization exists at present.