Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.
Nicholas A Turner,Batu K. Sharma-Kuinkel,Stacey A. Maskarinec,Emily M. Eichenberger,Pratik Shah,Manuela Carugati,Manuela Carugati,Thomas L. Holland,Vance G. Fowler,Vance G. Fowler +9 more
TL;DR: An overview of basic and clinical MRSA research is provided and the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA is explored.
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Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
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A high-throughput cell culture system based on capillary and centrifugal actions for rapid antimicrobial susceptibility testing.
TL;DR: The proposed capillary and centrifuge-based rapid AST system provides a useful tool for drug testing in cell-culture systems with user-friendly and high-throughput analysis and is validated in a systematic analysis that includes sample loading characteristics and AST trials with standard strains.
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Engineered lipid bicelle nanostructures for membrane-disruptive antibacterial applications
Tun Naw Sut,Tun Naw Sut,Elba R. Valle-González,Bo Kyeong Yoon,Soohyun Park,Joshua A. Jackman,Nam-Joon Cho +6 more
TL;DR: This work developed antibiotic-free, antibacterial bicellar nanostructures composed of a long-chain phospholipid and glycerol monolaurate, which is a monoglyceride that exhibits membrane-disruption inhibitory activity against various bacteria and membrane-enveloped viruses.
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Dolosigranulum pigrum cooperation and competition in human nasal microbiota
Silvio D. Brugger,Silvio D. Brugger,Silvio D. Brugger,Sara M Eslami,Melinda M. Pettigrew,Isabel F. Escapa,Isabel F. Escapa,Matthew T. Henke,Yong Kong,Katherine P. Lemon,Katherine P. Lemon +10 more
TL;DR: New insights into D. pigrum’s functions advance the field from compositional analysis to genomic and phenotypic experimentation on a potentially beneficial bacterial resident of the human upper respiratory tract and lay the foundation for future animal and clinical experiments.
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Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation.
Sabrina N Kline,Nicholas A Orlando,Alex J Lee,Meng-Jen Wu,Jing Zhang,Christine Youn,Laine E Feller,C. Pontaza,Dustin Dikeman,Nathachit Limjunyawong,Kaitlin Williams,Yu Wang,Daniela Cihakova,Elizabeth A Jacobsen,Scott K Durum,Luis A Garza,Xinzhong Dong,Nathan K. Archer +17 more
TL;DR: It is found that eosinophils had a comparable contribution to the skin inflammation as T cells, in a manner dependent on eosinophil-derived IL-17A and IL-17F production, which has implications in the pathogenesis of inflammatory skin diseases.
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A high throughput assay to measure Type VII secretion in Staphylococcus aureus
TL;DR: In this paper , the authors used binary technology to detect bioluminescence in 384-well plates of Staphylococcus aureus and found that high-throughput analysis of secretion in replicate cultures reveals overlapping distributions for T7+ and T7- populations highlighting a significant limitation of lowerthroughput methods.
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Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children
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TL;DR: These guidelines discuss the management of a variety of clinical syndromes associated with MRSA disease, including skin and soft tissue infections (SSTI), bacteremia and endocarditis, pneumonia, bone and joint infections, and central nervous system infections.
Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America
Leonard A. Mermel,Michael Allon,Emilio Bouza,Donald E. Craven,Patricia M. Flynn,Issam I Raad,Bart J. A. Rijnders,Robert J. Sherertz,David K. Warren,North Carolina +9 more
TL;DR: These updated guidelines replace the previous management guidelines published in 2001 and are intended for use by health care providers who care for patients who either have these infections or may be at risk for them.
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Kim Rutherford,Julian Parkhill,James Crook,Terry Horsnell,Peter M. Rice,Marie-Adèle Rajandream,Bart Barrell +6 more
TL;DR: Artemis is a DNA sequence visualization and annotation tool that allows the results of any analysis or sets of analyses to be viewed in the context of the sequence and its six-frame translation.
Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus.
Mark C. Enright,Nicholas P. J. Day,Catrin E. Davies,Sharon J Peacock,Sharon J Peacock,Brian G. Spratt +5 more
TL;DR: A multilocus sequence typing (MLST) scheme has been developed for Staphylococcus aureus and provides an unambiguous method for assigning MRSA and MSSA isolates to known clones or assigning them as novel clones via the Internet.
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