Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.
Nicholas A Turner,Batu K. Sharma-Kuinkel,Stacey A. Maskarinec,Emily M. Eichenberger,Pratik Shah,Manuela Carugati,Manuela Carugati,Thomas L. Holland,Vance G. Fowler,Vance G. Fowler +9 more
TL;DR: An overview of basic and clinical MRSA research is provided and the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA is explored.
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Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
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Citations
Cell-Free Culture Supernatants of Lactobacilli Modify the Expression of Virulence Factors Genes in Staphylococcus aureus
Mahnaz Ramezani,Nahid Zainodini,Hamid Hakimi,Ebrahim Rezazadeh Zarandi,Vahid Bagheri,Reza Bahramabadi,Mohammad Zare-Bidaki +6 more
TL;DR: Cell-free culture supernatants of probiotic bacteria can down-regulate the virulence genes and the presence of CFS in the food probably reduces diarrhea and vomiting caused by S. aureus as a food-borne pathogen.
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Staphylococcus aureus and biofilms: transmission, threats, and promising strategies in animal husbandry
Mengda Song,Qi Tang,Ya-tong Ding,Peng Tan,Yucheng Zhang,Tao Wang,Chenlong Zhou,Shenrui Xu,Mengwei Lyu,Yueyu Bai,Xi Ma +10 more
TL;DR: This review examines the transmission and threats of Staphylococcus aureus and its biofilms in animal husbandry, highlighting the harm caused and proposing strategies for removal and eradication using antimicrobial agents and other methods to ensure livestock health and safety.
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spa diversity of methicillin-resistant and -susceptible Staphylococcus aureus in clinical strains from Malaysia: a high prevalence of invasive European spa-type t032.
Sherry Usun Jones,Kek Heng Chua,Ching Hoong Chew,Chew Chieng Yeo,Fatimah Haslina Abdullah,Norlela Othman,Boon Pin Kee,Suat Moi Puah +7 more
TL;DR: In this paper, the spa types in Malaysian S. aureus isolates obtained from various clinical specimens were investigated and the most predominant spa types were t032 (50%) in MRSA, and t127 (19%) and t091 (16.7%), respectively.
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Phenol-Soluble Modulin-Mediated Aggregation of Community-Associated Methicillin-Resistant Staphylococcus Aureus in Human Cerebrospinal Fluid.
Deok Ryeong Kim,Yeonhee Lee,Hyeon Kyeong Kim,Wooseong Kim,Yun-Gon Kim,Yung Hun Yang,Jae Seok Kim,Hwang-Soo Joo +7 more
TL;DR: The differences in CSF distribution and PSM presence within the specific CSF environment are significant factors affecting bacterial cell aggregation.
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Expression and characterization of novel chimeric endolysin CHAPk-SH3bk against biofilm-forming methicillin-resistant Staphylococcus aureus.
Manisha Behera,Gagandeep Singh,Ashutosh Vats,Parmanand,Mayank Roshan,Devika Gautam,Chanchal Rana,Rajesh Kumar Kesharwani,Sachinandan De,Soma Mondal Ghorai +9 more
TL;DR: This study indicates an effective reduction of preformed MRSA biofilms of human and animal origin using novel chimeric construct CHAPk-SH3bk using the combination and shuffling of different domains of phage endolysin potentially increase its bacteriolytic effectiveness against MRSA.
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