Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia
Rae R. Matsumoto,Michael J. Seminerio,Ryan C. Turner,Matthew J. Robson,Linda Nguyen,Diane B. Miller,James P. O'Callaghan +6 more
TL;DR: This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature, and discusses central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia.
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About: This article is published in Pharmacology & Therapeutics. The article was published on 14 May 2014. and is currently open access.
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Citations
Bifunctional Behavior of Conformationally Constrained Methamphetamine Analogs: Unexpected Heteroclitic Immune Response and Antagonist Effects Altering Methamphetamine and Fentanyl Pharmacology
Sukhyun Lee,Lisa M. Eubanks,Bin Zhou,Kim D. Janda,Sukhyun Lee,Lisa M. Eubanks,Bin Zhou,Kim D. Janda +7 more
Abstract: Methamphetamine addiction is a growing global health crisis with no FDA-approved pharmacotherapies. Vaccination offers a promising therapeutic strategy, yet clinical translation has been limited by immune response inefficacy. Here, we evaluated three methamphetamine vaccine candidates: H1, a conventional hapten based on traditional drug-hapten-vaccine logic, and H2 and H3, two conformationally constrained analogs incorporating pyrrolidine and azetidine scaffolds, respectively. The rigidified hapten H2 produced an unprecedented heteroclitic immune response, with mature antibodies binding methamphetamine with an order of magnitude greater affinity than the immunizing scaffold. Although vaccine haptens are rarely assessed for intrinsic bioactivity, the pyrrolidine scaffold of H2, termed S1, exhibited distinct pharmacology, which was markedly divergent from methamphetamine. S1 is also capable of mitigating not only methamphetamine but also fentanyl-induced physiological effects. Methamphetamine conformational constraint offers a new tool for methamphetamine vaccine development as well as promising therapeutic agents for reversal of methamphetamine behavior and fentanyl-induced toxicity.
The Role of Hyperthermia in Methamphetamine-Induced Depression-Like Behaviors: Protective Effects of Coral Calcium Hydride
Xintao Wang,Bonan Tong,Rongji Hui,Congcong Hou,Zilu Zhang,Ludi Zhang,Bing Xie,Zhi Yu Ni,Bin Cong,Chunling Ma,Di Wen +10 more
TL;DR: CCH is an efficient hydrogen-rich agent, which has a potential therapeutic applicability in the treatment of METH abusers and significantly attenuated METH-induced hyperthermia, and administration of CCH after METH exposure also inhibited Meth-induced depression-like behaviors and reduced the hippocampal synaptic plasticity damage.
Climate, Heat, and the Limits of Medical Diagnostics: Lessons From “America's Hottest City"
David Sklar,Frederic W Hafferty,Pope Moseley +2 more
Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity.
TL;DR: Results indicate that activation of TAar1 potentiates MA‐induced hypothermia and TAAR1 confers sustained neuroprotection dependent on its thermoregulatory effects.
Hypotension, Severe Hyperthermia (42°C), Rhabdomyolysis, and Disseminated Intravascular Coagulation Induced by Lethal Dose of Methamphetamine.
TL;DR: This report presents a fatal case of methamphetamine overdose (>1.5 gms) that presented with hypotension, severe hyperthermia, and rigidity, complicated by rhabdomyolysis, acute renal failure, disseminated intravascular coagulation, and multiorgan failure.
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