Journal Article10.1016/J.FREERADBIOMED.2021.01.033
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects
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TL;DR: In this paper, the effects of Met on vascular smooth muscle cells (VSMCs) calcification were investigated in a rat aortic tissue and showed that upregulation of POSTN increased the sensitivity of cells to ferroptosis.
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About: This article is published in Free Radical Biology and Medicine. The article was published on 01 Mar 2021. The article focuses on the topics: Saturated fatty acid & Periostin.
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Citations
Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents
John Dawi,Scarlet Affa,Edgar R. Gonzalez,Yura Misakyan,David Nikoghosyan,Karim Hajjar,Samuel Kades,Sabrina Fardeheb,Hayk Mirzoyan,Vishwanath Venketaraman +9 more
TL;DR: Ferroptosis plays a significant role in cardiovascular diseases and cardiomyopathies, involving iron-induced phospholipid peroxidation and intricate cellular interactions. Its impact on myocardial ischemia-reperfusion injury and diabetes underscores its relevance in cardiovascular conditions. Understanding ferroptosis is crucial for developing novel therapeutic strategies targeting iron metabolism, antioxidant defenses, and the balance between polyunsaturated and monounsaturated fatty acids.
5
Mitochondrial DNA leakage triggers inflammation in age-related cardiovascular diseases
Wanyue Ding,Jingyu Chen,Lei Zhao,Shuang Wu,Xiaomei Chen,Hong Chen +5 more
TL;DR: Recent studies on mechanisms by which mtDNA promotes inflammation and aging-related cardiovascular diseases are summarized, and the potential value of mtDNA in early screening and as therapeutic targets is discussed.
4
Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies
01 Sep 2022
TL;DR: In this paper , the authors reviewed the recent findings reported on the mechanisms of myocardial damage due to hyperlipidemia and showed that metabolic diseases (eg, obesity and diabetes) and chemical poisoning can lead to hyper-lipidemic mycardial injury and necrosis.
4
Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells.
Yajun Chen,Liyun Feng,Jiali Huang,Qingchun Liang,Zirong Lan,Qian Dong,Yining Li,Xiuli Zhang,Jingsong Ou,Jianyun Yan +9 more
TL;DR: This study for the first time demonstrates that POVPC promotes vascular calcification via activation of VSMC ferroptosis, and reduces the levels of POVPC or inhibiting ferroptosis might provide a novel strategy to treat vascular calcification.
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Natural compounds efficacy in complicated diabetes: A new twist impacting ferroptosis.
Tingting Bao,Xiangyuan Zhang,Weinan Xie,Ying Wang,Xiuyang Li,Cheng Tang,Ying Ying Yang,Jun Sun,Jiaqi Gao,Tongyue Yu,Linhua Zhao,Xiaolin Tong +11 more
- 09 Oct 2023
TL;DR: This review summarized the potential treatment strategies of natural compounds as ferroptosis inhibitors to treat T2DM and its complications, providing potential lead compounds and natural phytochemical molecular nuclei for future drug research and development to intervene in ferroPTosis in T2 DM.
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References
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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Ferroptosis: process and function.
Yangchun Xie,Wen Hou,Xinxin Song,Yan Yu,Jin Huang,Xiaofang Sun,Rui Kang,Daolin Tang,Daolin Tang +8 more
TL;DR: Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity.
Ferroptosis as a p53-mediated activity during tumour suppression
TL;DR: It is shown that p53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non-apoptotic form of cell death, by repressing expression of SLC7A11, a key component of the Cystine/glutamate antiporter.
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
TL;DR: This review will provide a brief overview of lipid peroxidation, as well as key components involved in the ferroptotic cascade, focusing on established NRF2 target genes that mitigate these pathways, and the relevance of theNRF2-lipid per oxidation-ferroptosis axis in disease.
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Ferroptosis is an autophagic cell death process
TL;DR: It is reported that inhibition of ferritinophagy by blockage of autophagy or knockdown of NCOA4 abrogated the accumulation of ferroptosis-associated cellular labile iron and reactive oxygen species, as well as eventual ferroPTotic cell death.