Metaflammation in obesity and its therapeutic targeting
Michael W. Schleh,Heather L. Caslin,Jamie N Garcia,Mona Mashayekhi,Gitanjali Srivastava,A. B. Bradley,Alyssa H. Hasty +6 more
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TL;DR: The current literature on the roles of various immune cells in lean and obese adipose tissue and clinical approaches targeting inflammation are reviewed.
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Abstract: Obesity-associated inflammation is a systemic process that affects all metabolic organs. Prominent among these is adipose tissue, where cells of the innate and adaptive immune system are markedly changed in obesity, implicating these cells in a range of processes linking immune memory to metabolic regulation. Furthermore, weight loss and weight cycling have unexpected effects on adipose tissue immune populations. Here, we review the current literature on the roles of various immune cells in lean and obese adipose tissue. Within this context, we discuss pharmacological and nonpharmacological approaches to obesity treatment and their impact on systemic inflammation. Description This Review details innate and adaptive immune responses to obesity and weight regain in adipose tissue and clinical approaches targeting inflammation.
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TL;DR: The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence‐based interventions to address this problem.
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