Metabolite quantification and high-field MRS in breast cancer
Ihab S. Haddadin,Adeka McIntosh,Sina Meisamy,Curt Corum,Angela Lynn Styczynski Snyder,Nathaniel J. Powell,Michael T. Nelson,Douglas Yee,Michael Garwood,Patrick J. Bolan +9 more
TL;DR: This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high‐field MR scanning and quantitative methods.
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Abstract: In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have been made to evaluate the role of 1H MRS measurements of total choline-containing compounds in the management of patients with breast cancer. Current technological developments, including the use of high-field MR scanners and quantitative spectroscopic analysis methods, promise to increase the sensitivity and accuracy of breast MRS. This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high-field MR scanning and quantitative methods. Potential applications of these technologies for diagnosing suspicious lesions and monitoring response to chemotherapy are discussed.
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Citations
Optimized spectral analysis in magnetic resonance spectroscopy for early tumor diagnostics
Karen Belkić,Karen Belkić,Karen Belkić,Dževad Belkić +3 more
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TL;DR: In this article, the fast Pade transform (FPT) is applied to MRS time signals as encoded from patients with breast cancers and other cancers, with benign pathology and with normal tissue, as illustrated in Figure 1.
Human umbilical mesenchymal stem cell and its adipogenic differentiation: Profiling by nuclear magnetic resonance spectroscopy
TL;DR: NMR spectroscopy will be a promising tool for monitoring stem cell differentiation because several major metabolites, such as: choline, creatine, glutamate and myo-inositol, acetate, and some fatty acids/triglycerides, were observed in the MR spectroscopic pattern of HUMSCs and their adipogenic differentiation.
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Quantitative mapping of total choline in healthy human breast using proton echo planar spectroscopic imaging (PEPSI) at 3 Tesla
Chenguang Zhao,Patrick J. Bolan,Melanie Royce,Navneeth Lakkadi,Steven C. Eberhardt,Laurel O. Sillerud,Sang Joon Lee,Stefan Posse +7 more
TL;DR: To quantitatively measure tCho levels in healthy breasts using Proton‐Echo‐Planar‐Spectroscopic‐Imaging (PEPSI) and to assess the impact of exposure to proton-proton radiolysis on TCho levels.
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TL;DR: In this paper, an enhanced version of localized correlation spectroscopy (L-COSY) by introducing adiabatic radiofrequency (RF) pulses for localization in two dimensions is described.
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3.0 T proton magnetic resonance spectroscopy of the liver: Quantification of choline
TL;DR: Lipid accumulation could result from the increased fat in the body depending on age and BMI, and Lipid can mask the resonance signal of choline.
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