Metabolite quantification and high-field MRS in breast cancer
Ihab S. Haddadin,Adeka McIntosh,Sina Meisamy,Curt Corum,Angela Lynn Styczynski Snyder,Nathaniel J. Powell,Michael T. Nelson,Douglas Yee,Michael Garwood,Patrick J. Bolan +9 more
TL;DR: This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high‐field MR scanning and quantitative methods.
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Abstract: In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have been made to evaluate the role of 1H MRS measurements of total choline-containing compounds in the management of patients with breast cancer. Current technological developments, including the use of high-field MR scanners and quantitative spectroscopic analysis methods, promise to increase the sensitivity and accuracy of breast MRS. This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high-field MR scanning and quantitative methods. Potential applications of these technologies for diagnosing suspicious lesions and monitoring response to chemotherapy are discussed.
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References
Automatic quantitation of localized in vivo 1H spectra with LCModel
TL;DR: The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions using complete model spectra, rather than individual resonances, in order to incorporate maximum prior information into the analysis.
1.6K
The Return of the Frequency Sweep: Designing Adiabatic Pulses for Contemporary NMR
Michael Garwood,Lance DelaBarre +1 more
TL;DR: The classical adiabatic rapid passage is analyzed using vector models in different rotating frames of reference and ways to tailor modulation functions to best satisfy specific experimental needs are demonstrated.
969
7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images.
J. T Vaughan,Michael Garwood,Christopher M. Collins,Wanzhan Liu,Lance DelaBarre,Gregor Adriany,Peter Andersen,Hellmut Merkle,Rainer Goebel,Michael B. Smith,Kamil Ugurbil +10 more
TL;DR: Signal‐to‐noise ratio (SNR), RF field (B1), and RF power requirement for human head imaging were examined at 7T and 4T magnetic field strengths and were consistent with calculations performed using a human head model and Maxwell's equations.
931
Localized proton spectroscopy using stimulated echoes.
TL;DR: In this paper, a new method for spatially resolved NMR spectroscopy that takes advantage of stimulated echo signals is described, which is a single-step procedure minimizing rf power requirements and gradient switches.
819