Journal Article10.1016/0009-2797(94)03347-1
Metabolism and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl in pregnant and fetal rats
D.C. Morse,E. Klasson Wehler,M. van de Pas,A.Th.H.J. de Bie,P.J. van Bladeren,Abraham Brouwer +5 more
56
TL;DR: The metabolism and distribution of a single oral dose of 25 mumol 14C-labelled 3,3',4,4'-tetrachlorobiphenyl (14C-TCB) were investigated in pregnant female Wistar rats and their fetuses and hydroxylated metabolites of polychlorinated biphenyls may play a role in the development toxicity of these compounds.
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About: This article is published in Chemico-Biological Interactions. The article was published on 30 Mar 1995. The article focuses on the topics: Oral administration.
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Citations
Toxicological profile for polychlorinated biphenyls (PCBs)
Obaid Faroon,James N. Olson +1 more
- 01 Nov 2000
TL;DR: A toxicological profile for PCBs, Draft for Public Comment, was released in December 1998 as discussed by the authors, which supercedes any previously released draft or final profile, but no less than once every three years.
798
Metabolism and metabolites of polychlorinated biphenyls
Fabian A. Grimm,Dingfei Hu,Izabela Kania-Korwel,Hans-Joachim Lehmler,Gabriele Ludewig,Keri C. Hornbuckle,Michael W. Duffel,Åke Bergman,Larry W. Robertson +8 more
TL;DR: An overview of PCB metabolism is provided, and mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood are discussed.
Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions.
TL;DR: The tested plasticizers and phenols elicited endocrine-disrupting potential that can be mediated via interference with the estrogen and TH systems, and the observed mixture effect stresses the importance of considering the combined effect of the compounds for risk assessment of human health.
299
Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants
Abraham Brouwer,Ulf G. Ahlborg,Martin van den Berg,Linda S. Birnbaum,E. Ruud Boersma,Bart A.T.C. Bosveld,Michael S. Denison,L. Earl Gray,Lars Hagmar,Edel Holene,M Huisman,Sandra W. Jacobson,Joseph L. Jacobson,C. Koopman-Esseboom,Janna G. Koppe,Beverly M. Kulig,D.C. Morse,Gina Muckle,Richard E. Peterson,Pieter J J Sauer,Richard F. Seegal,Annette E. Smits-van Prooije,Bert C.L. Touwen,N. Weisglas-Kuperus,Gerhard Winneke +24 more
TL;DR: The lowest observable adverse effect levels (LOAELs) for developmental neurobehavioral and reproduction endpoints, based on body burden of TCDD-toxic equivalents (TEQs) in animals, are within the range of current background human body burdens.
293
Disposition of orally administered 2,2-Bis(4-hydroxyphenyl)propane (bisphenol A) in pregnant rats and the placental transfer to fetuses.
Osamu Takahashi,Shinshi Oishi +1 more
TL;DR: The results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.
251
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Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds : environmental and mechanistic considerations with support the development of toxic equivalency factors (TEFs)
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TL;DR: Using the rationale described in this paper, the most evironmentally threatening PCB congeners were assigned to four groups, and weak inducers and noninducing congeners have the least potential for toxicity.
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Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin
Martine C. Lans,E. Klasson-Wehler,Marcel Willemsen,Elise Meussen,Stephen Safe,Abraham Brouwer +5 more
TL;DR: A profound similarity in structural requirements for TTR binding between hydroxy-PCB, -PCDD and -PCDF metabolites and the physiological ligand, T4 is found, e.g. halogen substitution adjacent to the para hydroxy group, while planarity does not seem to influence the ligand-binding potency.
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