Journal Article10.4049/jimmunol.202.supp.56.2
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior
Michio Miyajima,Baihao Zhang,Matteo Guerrini,Yuki Sugiura,Sidonia Fagarasan +4 more
8
TL;DR: Enhanced incorporation of amino acids in activated T cells leads to serum decrease in amino acids, which leads to serotonin and dopamine decrease in brain and enhanced anxiety-like behavior and fear response in PD-1-deficient mice.
read more
About: This article is published in Journal of Immunology. The article was published on 01 May 2019.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Autophagy regulates lipid metabolism through selective turnover of NCoR1
Tetsuya Saito,Akiko Kuma,Akiko Kuma,Yuki Sugiura,Yoshinobu Ichimura,Miki Obata,Hiroshi Kitamura,Shujiro Okuda,Hyeon-Cheol Lee,Kazutaka Ikeda,Yumi Kanegae,Izumu Saito,Johan Auwerx,Hozumi Motohashi,Makoto Suematsu,Tomoyoshi Soga,Takehiko Yokomizo,Satoshi Waguri,Noboru Mizushima,Masaaki Komatsu,Masaaki Komatsu +20 more
TL;DR: It is shown that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies.
Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis
Wei Zhu,Bo-lun Zhou,Li-juan Rong,Li Ye,Hong-juan Xu,Yao Zhou,Xue-jun Yan,Weidong Liu,Bin Zhu,Lei Wang,Xing-jun Jiang,Caiping Ren +11 more
TL;DR: The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer.
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1.
TL;DR: The journey from the discovery of PD1 to its role as a breakthrough target in cancer immunotherapy is outlined and a mechanistic understanding of PD 1 signalling suggests a central function in setting the T cell activation threshold, thereby controlling T cell proliferation, differentiation, exhaustion and metabolic status is examined.
80
Neurocognitive Function, Psychosocial Outcome, and Health-Related Quality of Life of the First-Generation Metastatic Melanoma Survivors Treated with Ipilimumab.
Anne Rogiers,Christophe Leys,Justine Lauwyck,Adrian Schembri,Gil Awada,Julia Katharina Schwarze,Jennifer De Cremer,Peter Theuns,Paul Maruff,Mark De Ridder,Jan L. Bernheim,Bart Neyns +11 more
TL;DR: A majority of melanoma survivors treated with IPI continue to suffer from emotional distress and impairment in NCF, with special attention for survivors with a history of neuroendocrine or neurological irAE.
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
Xiao-Xing Liu,Wandi Xiong,Maosen Ye,Tangsheng Lu,Kai Yuan,Suhua Chang,Ying Han,Yongxiang Wang,Lin Lu,Yanping Bao +9 more
TL;DR: This comprehensive review of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development, encompassing viral invasion, replication, immune response, and multiorgan deficits which include respiratory system, cardiac system, central nervous system, peripheral nervous system as well as long COVID.
10