Open Access
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque
Joshua C. Bis,Maryam Kavousi,Nora Franceschini,Aaron Isaacs,Gonçalo R. Abecasis,Ulf Schminke,Wendy S. Post,Albert V. Smith,L. Adrienne Cupples,Hugh S. Markus,Reinhold E. Schmidt,Jennifer E. Huffman,Terho Lehtimäki,Jens Baumert,Thomas Muenzel,Susan R. Heckbert,Abbas Dehghan,Kari E. North,Ben A. Oostra,Steve Bevan,Eva-Maria Stoegerer,Caroline Hayward,Olli T. Raitakari,Christa Meisinger,Arne Schillert,Serena Sanna,Henry Voelzke,Yu-Ching Cheng,Bolli Thorsson,Caroline S. Fox,Kenneth Rice,Fernando Rivadeneira,Vijay Nambi,Eran Halperin,K. Petrovic,Leena Peltonen,H.-Erich Wichmann,Renate B. Schnabel,Marcus Doerr,Afshin Parsa,Thor Aspelund,Serkalem Demissie,Sekar Kathiresan,Muredach P. Reilly,Kent D. Taylor,André G. Uitterlinden,David Couper,Matthias Sitzer,Mika Kähönen,Thomas Illig,Philipp S. Wild,Marco Orru,Jan Luedemann,Alan R. Shuldiner,Gudny Eiriksdottir,Charles C. White,Jerome I. Rotter,Albert Hofman,Jochen Seissler,Tanja Zeller,Gianluca Usala,Florian Ernst,Lenore J. Launer,Ralph B. D'Agostino,Daniel H. O'Leary,Christie M. Ballantyne,Joachim Thiery,Andreas Ziegler,Edward G. Lakatta,Ravi Kumar Chilukoti,Tamara B. Harris,Philip A. Wolf,Bruce M. Psaty,Joseph F. Polak,Xia Li,Wolfgang Rathmann,Manuela Uda,Eric Boerwinkle,Norman Klopp,Helena Schmidt,James F. Wilson,Jorma Viikari,Wolfgang Koenig,Stefan Blankenberg,Anne B. Newman,Jacqueline C.M. Witteman,Gerardo Heiss,Cornelia M. van Duijn,Angelo Scuteri,Georg Homuth,Braxton D. Mitchell,Vilmundur Gudnason,Christopher J. O'Donnell +92 more
- 01 Jan 2011
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Abstract: Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10−8). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.
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Citations
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas,Stavroula Kanoni,Christina Willenborg,Martin Farrall,Themistocles L. Assimes,John R. Thompson,Erik Ingelsson,Danish Saleheen,Danish Saleheen,Jeanette Erdmann,Benjamin A. Goldstein,Kathleen Stirrups,Inke R. König,Jean-Baptiste Cazier,Åsa Johansson,Alistair S. Hall,Jong-Young Lee,Cristen J. Willer,John C. Chambers,Tõnu Esko,Lasse Folkersen,Anuj Goel,Elin Grundberg,Aki S. Havulinna,Weang K. Ho,Jemma C. Hopewell,Niclas Eriksson,Marcus E. Kleber,Kati Kristiansson,Per Lundmark,Leo-Pekka Lyytikäinen,Suzanne Rafelt,Dmitry Shungin,Dmitry Shungin,Rona J. Strawbridge,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Natalie R. van Zuydam,Benjamin F. Voight,Lindsay L. Waite,Weihua Zhang,Andreas Ziegler,Devin Absher,David Altshuler,David Altshuler,Anthony J. Balmforth,Inês Barroso,Inês Barroso,Peter S. Braund,Peter S. Braund,Christof Burgdorf,Simone Claudi-Boehm,David G. Cox,Maria Dimitriou,Ron Do,Ron Do,Alex S. F. Doney,Nour Eddine El Mokhtari,Per Eriksson,Krista Fischer,Pierre Fontanillas,Anders Franco-Cereceda,Bruna Gigante,Leif Groop,Stefan Gustafsson,Jorg Hager,Göran Hallmans,Bok Ghee Han,Sarah E. Hunt,Hyun Min Kang,Thomas Illig,Thorsten Kessler,Joshua W. Knowles,Genovefa Kolovou,Johanna Kuusisto,Claudia Langenberg,Cordelia Langford,Karin Leander,Marja-Liisa Lokki,Anders Lundmark,Mark I. McCarthy,Christa Meisinger,Olle Melander,Evelin Mihailov,Seraya Maouche,Andrew D. Morris,Martina Müller-Nurasyid,Kjell Nikus,John F. Peden,N. William Rayner,Asif Rasheed,Silke Rosinger,Diana Rubin,Moritz P. Rumpf,Arne Schäfer,Mohan U. Sivananthan,Ci Song,Alexandre F.R. Stewart,Sian Tsung Tan,Gudmundur Thorgeirsson,C. Ellen van der Schoot,Peter Wagner,Peter Wagner,George A. Wells,Philipp S. Wild,Tsun-Po Yang,Philippe Amouyel,Dominique Arveiler,Hanneke Basart,Michael Boehnke,Eric Boerwinkle,Paolo Brambilla,François Cambien,Adrienne Cupples,Adrienne Cupples,Ulf de Faire,Abbas Dehghan,Patrick Diemert,Stephen E. Epstein,Alun Evans,Marco M Ferrario,Jean Ferrières,Dominique Gauguier,Dominique Gauguier,Alan S. Go,Alison H. Goodall,Alison H. Goodall,Villi Gudnason,Stanley L. Hazen,Hilma Holm,Carlos Iribarren,Yangsoo Jang,Mika Kähönen,Frank Kee,Hyo-Soo Kim,Norman Klopp,Wolfgang Koenig,Wolfgang Kratzer,Kari Kuulasmaa,Markku Laakso,Reijo Laaksonen,Jiyoung Lee,Lars Lind,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Sarah Parish,Jeong E. Park,Nancy L. Pedersen,Annette Peters,Thomas Quertermous,Daniel J. Rader,Veikko Salomaa,Eric E. Schadt,Svati H. Shah,Juha Sinisalo,Klaus Stark,Kari Stefansson,Kari Stefansson,David-Alexandre Trégouët,Jarmo Virtamo,Lars Wallentin,Nicholas J. Wareham,Martina E. Zimmermann,Markku S. Nieminen,Christian Hengstenberg,Manjinder S. Sandhu,Manjinder S. Sandhu,Tomi Pastinen,Ann-Christine Syvänen,G. Kees Hovingh,George Dedoussis,Paul W. Franks,Paul W. Franks,Paul W. Franks,Terho Lehtimäki,Andres Metspalu,Pierre Zalloua,Agneta Siegbahn,Stefan Schreiber,Samuli Ripatti,Samuli Ripatti,Stefan Blankenberg,Markus Perola,Robert Clarke,Bernhard O. Boehm,Christopher J. O'Donnell,Muredach P. Reilly,Winfried März,Winfried März,Rory Collins,Sekar Kathiresan,Sekar Kathiresan,Anders Hamsten,Jaspal S. Kooner,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,John Danesh,Colin N. A. Palmer,Robert Roberts,Hugh Watkins,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani +204 more
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