Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.
TL;DR: This study adds to the evidence that ALDH2 GA/AA genotype increases the risk of AD among East Asian men, although the effect size is moderate.
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Abstract: Contexte: L'association entre le polymorphisme du gene de l'aldehyde deshydrogenase 2 (ALDH2) et la maladie d'Alzheimer (MA) est controversee et elie a ete examinee seulement au cours d'etudes faites chez un petit nombre de sujets. Nous avons effectue une meta-analyse pour evaluer l'association transversale de variations dans le gene de l'ALDH2 et le risque de MA dans des populations de l'Asie de l'Est. Methode: Nous avons identifie les etudes dans MEDLINE, EMBASE, J-STAGE et dans les bases de donnees de China National Knowledge Internet, du 1er janvier 1994 au 1er novembre 2010, sans restriction quant a la langue de publication. Les donnees ont ete recueillies selon un protocole standardise. Resultats: Nous avons identifie 4 etudes portant sur un total de 821 patients atteints de MA et 1380 temoins en bonne sante, qui rencontraient les criteres etablis pour l'analyse. La variante genotypique GA/AA du gene de l'ALDH2 n'etait pas associee a un risque accru de MA (RC = 1,35; IC a 95%: 0,75 a 2,42; p = 0,32), meme apres ajustement pour la presence de l'allele epsilon 4 du gene de l'apolipoproteine E. Cependant, dans les analyses de sous-groupes, l'association etait significative chez les hommes (RC = 1,72 ; IC a 95%: 1,10 a 2,67; p = 0,02). Conclusions: Cette etude appuie la notion que le genotype GA/AA du gene de l'ALDH2 augmente le risque de MA chez les hommes de l'Asie de l'Est, mais que cet effet est modere.
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Thomas Münzel,Andreas Daiber +1 more
TL;DR: It is revealed that during bioconversion of nitroglycerin and in the presence of reactive oxygen and nitrogen species the active site thiols of ALDH-2 are oxidized and the enzyme activity is lost, which represents a useful marker for cardiovascular oxidative stress.
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