Journal Article10.1002/SMLL.202000436
Mesoporous Silica Supported Silver-Bismuth Nanoparticles as Photothermal Agents for Skin Infection Synergistic Antibacterial Therapy.
Changyu Cao,Wei Ge,Jiajia Yin,Dongliang Yang,Wenjun Wang,Xuejiao Song,Yanling Hu,Jie Yin,Xiaochen Dong,Xiaochen Dong +9 more
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TL;DR: In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus, and in vivo results confirm that Ag-Bi@SiO2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
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Abstract: The emergence of multidrug resistant bacteria has resulted in plenty of stubborn nosocomial infections and severely threatens human health. Developing novel bactericide and therapeutic strategy is urgently needed. Herein, mesoporous silica supported silver-bismuth nanoparticles (Ag-Bi@SiO2 NPs) are constructed for synergistic antibacterial therapy. In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus (MRSA). Besides, under laser irradiation, Ag-Bi@SiO2 NPs at 100 µg mL-1 can effectively obliterate mature MRSA biofilm and cause a 69.5% decrease in the biomass, showing a better therapeutic effect than Bi@SiO2 NPs with laser (26.8%) or Ag-Bi@SiO2 NPs without laser treatment (30.8%) groups. More importantly, in vivo results confirm that ≈95.4% of bacteria in abscess are killed and the abscess ablation is accelerated using the Ag-Bi@SiO2 NPs antibacterial platform. Therefore, Ag-Bi@SiO2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
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Additional file 1 of Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing
Wang Xin-yuan,Teng Jia-Hui,Xie Zhi-gang,Zheng Min +3 more
- 12 Aug 2022
Abstract: Additional file 1: Figure S1. Zeta potential of CDs. Figure S2. Antimicrobial assay of CD110 and CD1100 against E. coli. Figure S3. Antimicrobial assay of CD110 and CD1100 against S. aureus. Figure S4. Antimicrobial assay of Plys toward E. coli and S. aureus. Figure S5. Antimicrobial assay of Plys toward S. aureus with LB agar. Figure S6. MTT assay of CD31 toward L929 cells. Figure S7. MTT assay of Plys toward L929 cells. Figure S8. UV-vis spectrum of CD31 in deionized water. Figure S9. Photoluminescent spetra of (a) CD31 aqueous solution and (b) CD-Plys under the excitation of different wavelengths. Figure S10. FT-IR spectra of CD31 (black solid line), Plys (red solid line) and CD-Plys (blue solid line). Figure S11. The X-ray diffraction pattern of CD31 (black), Plys (red) and CD-Plys hydrogel (blue). Figure S12. Zeta potentials of CD31, Plys and CD-Plys hydrogel. Figure S13. The hemolysis assay of PBS, CD-Plys and Triton X-100. Figure S14. MTT assay of CD-Plys with direct contact with L929 cells for 12, 24 and 48 h.
Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma
Zhe Fan,Chengjun Zhuang,Shuang Wang,Yewei Zhang +3 more
TL;DR: This study reviews the application of photodynamic and photothermal therapies in treating hepatocellular carcinoma (HCC), highlighting their potential as effective alternatives to traditional treatments, particularly for multinodular HCC cases with high recurrence rates.
Functionalized Mesoporous Polydopamine Nanocarrier with Near-Infrared Laser-Trigged NO Release and Photothermal Effects for the Killing of Pathogenic Bacteria
Huajuan Wang,Jiale Ma,Ming-Ling Sun,Han Zou,Hongxun Wang,Min Zhou +5 more
TL;DR: Functionalized mesoporous polydopamine nanocarrier with near-infrared laser-trigged NO release and photothermal effects for the killing of pathogenic bacteria. The nanoplatform exhibits high antibacterial activity against Gram-negative and Gram-positive bacteria and mature biofilm.
Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis.
Shihang Mo,Kaiwei Tang,Qing Liao,Lingxia Xie,Yuzheng Wu,Guomin Wang,Qingdong Ruan,Ang Gao,Yuanliang Lv,Kaiyong Cai,Liping Tong,Zhengwei Wu,Paul K. Chu,Huaiyu Wang +13 more
TL;DR: In this article , tilted and vertical nanolamellar structures are fabricated on semi-crystalline polyether-ether-ketone (PEEK) via argon plasma treatment with or without pre-annealing.
References
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh,Young Jik Kwon +1 more
TL;DR: This review summarizes emerging efforts in combating against infectious diseases, particularly using antimicrobial NPs and antibiotics delivery systems as new tools to tackle the current challenges in treating infectious diseases.
1.8K
Effect of silver on burn wound infection control and healing: review of the literature.
TL;DR: The present review aims at examining all available evidence about effects of silver on wound infection control and on wound healing trying to determine the practical therapeutic balance between antimicrobial activity and cellular toxicity.
1.3K
Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
TL;DR: Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo.
922
Antibiotic use and its consequences for the normal microbiome
TL;DR: The cost that an antibiotic exerts on an individual’s own health via the collateral damage of the drug on bacteria that normally live on or in healthy humans: the authors' microbiota is illustrated.
775
Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy
Gongyuan Liu,Jianhua Zou,Qianyun Tang,Xiaoyan Yang,Yewei Zhang,Qi Zhang,Wei Huang,Peng Chen,Jinjun Shao,Xiaochen Dong +9 more
TL;DR: In vitro and in vivo experiments disclose that Ti3C2-DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.
591