Journal Article10.1002/SMLL.202000436
Mesoporous Silica Supported Silver-Bismuth Nanoparticles as Photothermal Agents for Skin Infection Synergistic Antibacterial Therapy.
Changyu Cao,Wei Ge,Jiajia Yin,Dongliang Yang,Wenjun Wang,Xuejiao Song,Yanling Hu,Jie Yin,Xiaochen Dong,Xiaochen Dong +9 more
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TL;DR: In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus, and in vivo results confirm that Ag-Bi@SiO2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
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Abstract: The emergence of multidrug resistant bacteria has resulted in plenty of stubborn nosocomial infections and severely threatens human health. Developing novel bactericide and therapeutic strategy is urgently needed. Herein, mesoporous silica supported silver-bismuth nanoparticles (Ag-Bi@SiO2 NPs) are constructed for synergistic antibacterial therapy. In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus (MRSA). Besides, under laser irradiation, Ag-Bi@SiO2 NPs at 100 µg mL-1 can effectively obliterate mature MRSA biofilm and cause a 69.5% decrease in the biomass, showing a better therapeutic effect than Bi@SiO2 NPs with laser (26.8%) or Ag-Bi@SiO2 NPs without laser treatment (30.8%) groups. More importantly, in vivo results confirm that ≈95.4% of bacteria in abscess are killed and the abscess ablation is accelerated using the Ag-Bi@SiO2 NPs antibacterial platform. Therefore, Ag-Bi@SiO2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
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References
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh,Young Jik Kwon +1 more
TL;DR: This review summarizes emerging efforts in combating against infectious diseases, particularly using antimicrobial NPs and antibiotics delivery systems as new tools to tackle the current challenges in treating infectious diseases.
1.8K
Effect of silver on burn wound infection control and healing: review of the literature.
TL;DR: The present review aims at examining all available evidence about effects of silver on wound infection control and on wound healing trying to determine the practical therapeutic balance between antimicrobial activity and cellular toxicity.
1.3K
Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
TL;DR: Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo.
922
Antibiotic use and its consequences for the normal microbiome
TL;DR: The cost that an antibiotic exerts on an individual’s own health via the collateral damage of the drug on bacteria that normally live on or in healthy humans: the authors' microbiota is illustrated.
775
Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy
Gongyuan Liu,Jianhua Zou,Qianyun Tang,Xiaoyan Yang,Yewei Zhang,Qi Zhang,Wei Huang,Peng Chen,Jinjun Shao,Xiaochen Dong +9 more
TL;DR: In vitro and in vivo experiments disclose that Ti3C2-DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.
591