Journal Article10.1002/SMLL.202000436
Mesoporous Silica Supported Silver-Bismuth Nanoparticles as Photothermal Agents for Skin Infection Synergistic Antibacterial Therapy.
Changyu Cao,Wei Ge,Jiajia Yin,Dongliang Yang,Wenjun Wang,Xuejiao Song,Yanling Hu,Jie Yin,Xiaochen Dong,Xiaochen Dong +9 more
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TL;DR: In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus, and in vivo results confirm that Ag-Bi@SiO2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
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Abstract: The emergence of multidrug resistant bacteria has resulted in plenty of stubborn nosocomial infections and severely threatens human health. Developing novel bactericide and therapeutic strategy is urgently needed. Herein, mesoporous silica supported silver-bismuth nanoparticles (Ag-Bi@SiO2 NPs) are constructed for synergistic antibacterial therapy. In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus (MRSA). Besides, under laser irradiation, Ag-Bi@SiO2 NPs at 100 µg mL-1 can effectively obliterate mature MRSA biofilm and cause a 69.5% decrease in the biomass, showing a better therapeutic effect than Bi@SiO2 NPs with laser (26.8%) or Ag-Bi@SiO2 NPs without laser treatment (30.8%) groups. More importantly, in vivo results confirm that ≈95.4% of bacteria in abscess are killed and the abscess ablation is accelerated using the Ag-Bi@SiO2 NPs antibacterial platform. Therefore, Ag-Bi@SiO2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
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Citations
NIR as a "trigger switch" for rapid phase change, on-demand release, and photothermal synergistic antibacterial treatment with chitosan-based temperature-sensitive hydrogel.
TL;DR: A photothermal synergistic chitosan-based temperature-sensitive hydrogel, h-EGF-CS/β-GP-MPDA@Cip, with the unique properties of rapid phase transition and drug release under near-infrared light (NIR) was developed in this article.
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Silica-supported near-infrared carbon dots and bicarbonate nanoplatform for triple synergistic sterilization and wound healing promotion therapy
TL;DR: Wang et al. as mentioned in this paper developed silica-supported near-infrared carbon dots and bicarbonate (BC) nanoplatform (BC/QPCuRC@MSiO2@PDA), which possess triple synergistic antibacterial including quaternary ammonium compounds, photothermal therapy (PTT), and photodynamic therapy (PDT).
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Rapid sterilisation and diabetic cutaneous regeneration using cascade bio-heterojunctions through glucose oxidase-primed therapy.
TL;DR: In this paper , a photo-activated cascade bio-heterojunctions (C-bio-HJs) for rapid sterilization and diabetic cutaneous regeneration was developed for rapid wound regeneration.
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Silver Nanoparticles Attenuate the Antimicrobial Activity of the Innate Immune System by Inhibiting Neutrophil-Mediated Phagocytosis and Reactive Oxygen Species Production
TL;DR: In this paper, the effect of materials on the antibacterial ability of the immune system, and in particular of neutrophils, was explored using ex vivo models and in vitro experiments.
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Near‐Infrared Light‐Activatable Bismuth‐Based Nanomaterials for Antibacterial and Antitumor Treatment
TL;DR: It is believed that the emerging NIR light‐activatable bismuth‐based nanomaterials can realize the actual antibacterial and antitumor via unremitting efforts of scientific researchers in the near future.
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