Mesenchymal stem cells and their derived exosomes for ALI/ARDS: A promising therapy
Dan Liang,Chang Liu,Mei Yang +2 more
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TL;DR: Future research should focus on the possible mechanisms of MSCs and their derived exosomes for the treatment of ALI/ARDS and open up new avenues for their clinical applications.
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Abstract: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious clinical syndrome with a high morbidity and mortality. Presently, therapeutic approaches for ALI/ARDS primarily revolve around symptomatic supportive care encompassing mechanical ventilation and fluid management. Regrettably, the prognosis for most ALI/ARDS patients remains bleak due to the absence of effective treatment strategies. Even survivors of ALI/ARDS may have long-term pulmonary dysfunction and cognitive impairment. The quality of life has been seriously compromised. The emergence of mesenchymal stem cells (MSCs) and their exosomes has opened up an expansive realm of potential and optimism for addressing the plight of ALI/ARDS patients, as MSCs and their derived exosomes exhibit multifaceted capabilities, including anti-inflammatory properties, facilitation of tissue repair and regeneration, and apoptosis inhibition. Therefore, future research should focus on the possible mechanisms of MSCs and their derived exosomes for the treatment of ALI/ARDS and open up new avenues for their clinical applications.
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Citations
Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications
Xinyu Qiao,Junhao Yin,Liang Li,Xiujing Feng +3 more
- 25 Apr 2024
TL;DR: This comprehensive review summarizes the involvement of endothelial cells and their intricate interplay with immune cells and stromal cells, including pulmonary epithelial cells and fibroblasts, in the pathogenesis of sepsis-induced ALI/ARDS, with particular emphasis placed on discussing the several pivotal pathways implicated in this process.
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Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine
Shafiqa Rajput,Bushra Kiran Naeem,Anwar Tawik Ali,Asmat Salim,Irfan Khan +4 more
TL;DR: This study proposes the development of a novel protocol for efficiently expanding stem cell population to address the growing demand for larger stem cell doses needed for cellular transplantation and will significantly improve the feasibility of stem cell based therapies.
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Umbilical cord MSC-derived exosomes improve alveolar macrophage function and reduce LPS-induced acute lung injury.
Enhai Cui,Lu Lv,Bin Wang,Liqin Li,Huadong Lu,Feng Hua,Wenyan Chen,Na Chen,Liwei Yang,Ruo Cai Pan +9 more
TL;DR: The study demonstrates that UC-MSC-derived exosomes effectively improved the metabolic function of alveolar macrophages and promoted their shift to an anti-inflammatory phenotype, leading to a reduction in ALI.
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Mesenchymal stromal cell therapy for COVID-19 acute respiratory distress syndrome: a double-blind randomised controlled trial.
María Esther Martínez-Muñoz,Concepción Payares-Herrera,Inés Lipperheide,R. Malo de Molina,Isabel Salcedo,Rosalía Alonso,Trinidad Martín-Donaire,Rocío Sánchez,Rocío Zafra,Miguel García-Berciano,Andrea Trisán-Alonso,Manuel Pérez-Torres,Antonio Ramos-Martínez,Piedad Ussetti,J. J. Rubio,Cristina Avendaño-Solà,Rafael F Duarte +16 more
TL;DR: This double-blind RCT assessed MSC therapy in 20 COVID-19 patients with ARDS, showing no significant increase in PaO2/FiO2 ratio by day 7, but improved clinical recovery, shorter hospital stay, and safety in the MSC group.
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Protective Effect of Shenfu Injection against Sepsis-induced Acute Lung Injury by Suppressing Inflammation and Apoptosis Through the Regulation of the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway
Li-Juan Cao,Hai-Tang Xie,Zhong-Xia Chu,Yue Ma +3 more
TL;DR: SFI effectively reduces inflammation and apoptosis in sepsis-induced ALI by regulating the JAK2/STAT3 pathway.
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Advances in the use of exosomes for the treatment of ALI/ARDS
Chang Liu,Kun Xiao,Lixin Xie +2 more
TL;DR: The possible mechanisms of exosomes in ALi/ARDS are discussed to facilitate the development of innovative treatments for ALI/ARDS.
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Mehdi Hassanpour,Jafar Rezaie,Masoud Darabi,Amirataollah Hiradfar,Reza Rahbarghazi,Mohammad Nouri +5 more
TL;DR: Autophagy modulation could alter differentiation potency of CD146+cells which is important in cardiac regeneration and the increase of exosome biogenesis and secretion to the supernatant in cells treated with HCQ compared to the Met groups.