Mesenchymal stem cells and their derived exosomes for ALI/ARDS: A promising therapy
Dan Liang,Chang Liu,Mei Yang +2 more
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TL;DR: Future research should focus on the possible mechanisms of MSCs and their derived exosomes for the treatment of ALI/ARDS and open up new avenues for their clinical applications.
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Abstract: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious clinical syndrome with a high morbidity and mortality. Presently, therapeutic approaches for ALI/ARDS primarily revolve around symptomatic supportive care encompassing mechanical ventilation and fluid management. Regrettably, the prognosis for most ALI/ARDS patients remains bleak due to the absence of effective treatment strategies. Even survivors of ALI/ARDS may have long-term pulmonary dysfunction and cognitive impairment. The quality of life has been seriously compromised. The emergence of mesenchymal stem cells (MSCs) and their exosomes has opened up an expansive realm of potential and optimism for addressing the plight of ALI/ARDS patients, as MSCs and their derived exosomes exhibit multifaceted capabilities, including anti-inflammatory properties, facilitation of tissue repair and regeneration, and apoptosis inhibition. Therefore, future research should focus on the possible mechanisms of MSCs and their derived exosomes for the treatment of ALI/ARDS and open up new avenues for their clinical applications.
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Citations
Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications
Xinyu Qiao,Junhao Yin,Liang Li,Xiujing Feng +3 more
- 25 Apr 2024
TL;DR: This comprehensive review summarizes the involvement of endothelial cells and their intricate interplay with immune cells and stromal cells, including pulmonary epithelial cells and fibroblasts, in the pathogenesis of sepsis-induced ALI/ARDS, with particular emphasis placed on discussing the several pivotal pathways implicated in this process.
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Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine
Shafiqa Rajput,Bushra Kiran Naeem,Anwar Tawik Ali,Asmat Salim,Irfan Khan +4 more
TL;DR: This study proposes the development of a novel protocol for efficiently expanding stem cell population to address the growing demand for larger stem cell doses needed for cellular transplantation and will significantly improve the feasibility of stem cell based therapies.
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Umbilical cord MSC-derived exosomes improve alveolar macrophage function and reduce LPS-induced acute lung injury.
Enhai Cui,Lu Lv,Bin Wang,Liqin Li,Huadong Lu,Feng Hua,Wenyan Chen,Na Chen,Liwei Yang,Ruo Cai Pan +9 more
TL;DR: The study demonstrates that UC-MSC-derived exosomes effectively improved the metabolic function of alveolar macrophages and promoted their shift to an anti-inflammatory phenotype, leading to a reduction in ALI.
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Mesenchymal stromal cell therapy for COVID-19 acute respiratory distress syndrome: a double-blind randomised controlled trial.
María Esther Martínez-Muñoz,Concepción Payares-Herrera,Inés Lipperheide,R. Malo de Molina,Isabel Salcedo,Rosalía Alonso,Trinidad Martín-Donaire,Rocío Sánchez,Rocío Zafra,Miguel García-Berciano,Andrea Trisán-Alonso,Manuel Pérez-Torres,Antonio Ramos-Martínez,Piedad Ussetti,J. J. Rubio,Cristina Avendaño-Solà,Rafael F Duarte +16 more
TL;DR: This double-blind RCT assessed MSC therapy in 20 COVID-19 patients with ARDS, showing no significant increase in PaO2/FiO2 ratio by day 7, but improved clinical recovery, shorter hospital stay, and safety in the MSC group.
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Protective Effect of Shenfu Injection against Sepsis-induced Acute Lung Injury by Suppressing Inflammation and Apoptosis Through the Regulation of the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway
Li-Juan Cao,Hai-Tang Xie,Zhong-Xia Chu,Yue Ma +3 more
TL;DR: SFI effectively reduces inflammation and apoptosis in sepsis-induced ALI by regulating the JAK2/STAT3 pathway.
References
Human mesenchymal stem cells treatment for severe COVID-19: 1-year follow-up results of a randomized, double-blind, placebo-controlled trial
Wei-Fen Xie,Fu-Sheng Wang +1 more
- 01 Jan 2022
TL;DR: In this article , the authors evaluated the 1-year outcomes in patients with severe COVID-19, who were recruited in their previous UC-MSC clinical trial, and the results showed that the long-term consequences of human umbilical cord-derived mesenchymal stem cell treatment for COVID19 patients are yet to be reported.
100
Mesenchymal stem cell-secreted soluble signaling molecules potentiate tumor growth.
Wei Zhu,Ling Huang,Yahong Li,Hui Qian,Xiuhong Shan,Yongmin Yan,Fei Mao,Xiaosheng Wu,Wenrong Xu +8 more
TL;DR: It is found that pretreatment of tumor cells SGC-7901 with a single dose of human MSC-conditioned medium (hMSC-CM) in vitro is sufficient to potentiate tumor growth comparable to the effect of MSC co-injection in vivo in mouse xenograft models.
90
Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia
Jiazeng Xia,Yigang Chen +1 more
TL;DR: Wang et al. as mentioned in this paper demonstrated that nebulization of mesenchymal stem cells (MSCs) derived exosomes is a novel method that might be utilized in the treatment of COVID-19 pneumonia.
Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges.
Mahdi Ahmadi,Jafar Rezaie +1 more
TL;DR: Exosomes‐therapy may serve as a new approach to combat ageing, but the translation of preclinical results to clinic needs more extensive investigation on exosomes both on their biology and related techniques.
81
Tumor-derived extracellular vesicles: The metastatic organotropism drivers
01 Jan 2022
TL;DR: In this paper , the authors discuss the role of extracellular vesicles (EVs) in pre-metastatic niche formation and organotropic metastasis in cancer.
81