Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
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TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
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About: This article is published in Cancer Cell. The article was published on 09 Sep 2013. and is currently open access. The article focuses on the topics: Mesenchymal Glioblastoma & Tumor microenvironment.
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TL;DR: In this article , NEDD4 E3 ubiquitin ligase polyubiquitinates TUSC2 at residue K71, and the mutant is resistant to proteasomal degradation.
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TL;DR: Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype induces apoptosis in both sensitive and resistant GSCs and abrogates acquired chemoresistance.
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TL;DR: In this paper , the authors investigated the role of ADAMTS3 in GSC proliferation and self-renewal activities and tumorigenesis in orthotopic xenograft models.
Additional file 1 of EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion
Chen Qun,Jin Jing,Huang Xin,Wu Fan,Huang Hong-guang,Zhan Ren-ya +5 more
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Abstract: Additional file 1.
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TL;DR: DAMID is a web-accessible program that integrates functional genomic annotations with intuitive graphical summaries that assists in the interpretation of genome-scale datasets by facilitating the transition from data collection to biological meaning.
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G.W. Verhaak,Katherine A. Hoadley,Elizabeth Purdom,Victoria Wang,Yuan-yuan Qi,Matthew D. Wilkerson,C. Ryan Miller,Li Ding,Todd R. Golub,Jill P. Mesirov,Gabriele Alexe,Michael S. Lawrence,Michael O'Kelly,Pablo Tamayo,Barbara A. Weir,Stacey Gabriel,Wendy Winckler,Supriya Gupta,Lakshmi Jakkula,Heidi S. Feiler,J. Graeme Hodgson,C. David James,Jann N. Sarkaria,Cameron Brennan,Ari B. Kahn,Paul T. Spellman,Richard K. Wilson,Terence P. Speed,Terence P. Speed,Joe W. Gray,Matthew Meyerson,Gad Getz,Charles M. Perou,Charles M. Perou,D. Neil Hayes +34 more
TL;DR: A robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes is described and multidimensional genomic data is integrated to establish patterns of somatic mutations and DNA copy number.
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MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
Monika E. Hegi,Annie-Claire Diserens,Thierry Gorlia,Marie-France Hamou,Nicolas de Tribolet,Nicolas de Tribolet,Michael Weller,Johan M. Kros,Johannes A. Hainfellner,Warren P. Mason,Luigi Mariani,Jacoline E C Bromberg,Peter Hau,René O. Mirimanoff,J. Gregory Cairncross,Robert C. Janzer,Roger Stupp +16 more
TL;DR: Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylation of theMGMT promoter did notHave such a benefit and were assigned to only radiotherapy.
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