Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
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TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
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About: This article is published in Cancer Cell. The article was published on 09 Sep 2013. and is currently open access. The article focuses on the topics: Mesenchymal Glioblastoma & Tumor microenvironment.
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Citations
Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme.
Shin Heon Lee,Shin Heon Lee,Hyung-Joon Kwon,Saewhan Park,Chan Il Kim,Haseo Ryu,Sung-Soo Kim,Jong Bae Park,Jeong Taik Kwon +8 more
TL;DR: In this paper, a dual inhibitor targeting macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) by 4-iodo-6-phenylpyrimidine (4-IPP) was shown to downregulate stemness phenotype, intracellular signaling cascades, and induce apoptosis in proneural glioma stem cells.
The Role of Mesenchymal Reprogramming in Malignant Clonal Evolution and Intra-Tumoral Heterogeneity in Glioblastoma
TL;DR: The role of mesenchymal reprogramming in malignant clonal evolution and intra-tumoral heterogeneity in glioblastoma drives therapeutic refractoriness and poor patient outcomes.
Co-administration of temozolomide (TMZ) and the experimental therapeutic targeting miR-10b, profoundly affects the tumorigenic phenotype of human glioblastoma cells
TL;DR: In this article , an experimental therapeutic consisting of anti-miR10b antagomirs conjugated to iron oxide nanoparticles was used to suppress miR-10b in high-grade glioblastoma multiforme (GBM) cells.
ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma
Guanzhang Li,Yiming Li,Xing Liu,Zheng Wang,Chuanbao Zhang,Fan Wu,Haoyu Jiang,Wenlong Zhang,Zhaoshi Bao,Yongzhi Wang,Jinquan Cai,Liang Zhao,Ulf Dietrich Kahlert,Tao Jiang,Wei Zhang +14 more
TL;DR: ALDH1A3-based molecular classification scheme can help to improve guidance for prognosis forecasting and individualized treatment decision making for GBM patients and can predict 1, 2, and 3-year survival rates of GBMs precisely.
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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G.W. Verhaak,Katherine A. Hoadley,Elizabeth Purdom,Victoria Wang,Yuan-yuan Qi,Matthew D. Wilkerson,C. Ryan Miller,Li Ding,Todd R. Golub,Jill P. Mesirov,Gabriele Alexe,Michael S. Lawrence,Michael O'Kelly,Pablo Tamayo,Barbara A. Weir,Stacey Gabriel,Wendy Winckler,Supriya Gupta,Lakshmi Jakkula,Heidi S. Feiler,J. Graeme Hodgson,C. David James,Jann N. Sarkaria,Cameron Brennan,Ari B. Kahn,Paul T. Spellman,Richard K. Wilson,Terence P. Speed,Terence P. Speed,Joe W. Gray,Matthew Meyerson,Gad Getz,Charles M. Perou,Charles M. Perou,D. Neil Hayes +34 more
TL;DR: A robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes is described and multidimensional genomic data is integrated to establish patterns of somatic mutations and DNA copy number.
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MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
Monika E. Hegi,Annie-Claire Diserens,Thierry Gorlia,Marie-France Hamou,Nicolas de Tribolet,Nicolas de Tribolet,Michael Weller,Johan M. Kros,Johannes A. Hainfellner,Warren P. Mason,Luigi Mariani,Jacoline E C Bromberg,Peter Hau,René O. Mirimanoff,J. Gregory Cairncross,Robert C. Janzer,Roger Stupp +16 more
TL;DR: Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylation of theMGMT promoter did notHave such a benefit and were assigned to only radiotherapy.
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