Journal Article10.1111/J.2042-7158.1994.TB03871.X
Menthol and related cooling compounds.
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Citations
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
TL;DR: These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
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Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
TL;DR: Ten new agonists and three antagonists of TRPM8 are identified and it is found that, in contrast to VR1,TRPM8 is inhibited rather than potentiated by protons.
Menthol: a natural analgesic compound
Nicoletta Galeotti,Lorenzo Di Cesare Mannelli,Gabriela Mazzanti,Alessandro Bartolini,Carla Ghelardini +4 more
TL;DR: Results indicate that (-)-menthol is endowed with analgesic properties mediated through a selective activation of kappa-opioid receptors.
401
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References
Effect of menthol on the bladder cooling reflex in the cat.
S. Lindström,L. Mazières +1 more
TL;DR: It is proposed that the bladder cooling reflex originates from cold receptors in the bladder and urethral walls, and resembles the effect of menthol on cutaneous cold receptors.
68
The effects of D and L isomers of menthol upon nasal sensation of airflow.
TL;DR: Findings demonstrate that L-Menthol exerts a specific action upon nasal sensory nerve endings, which are responsible for the subjective appreciation of nasal airflow.
63
Menthol Cigarette Smoking and Oesophageal Cancer
TL;DR: Results of logistic regression analyses performed to account for potential confounding factors showed a marginally significant decrease in risk among male short term (less than 10 years) menthol smokers versus male never-menthol smokers but no increased risk for menthol smoking of longer duration.
61
Effects of a topically applied counterirritant (Eucalyptamint) on cutaneous blood flow and on skin and muscle temperatures. A placebo-controlled study
TL;DR: The results of this study suggested that the new product of counterirritant, Eucalyptamint, produced significant physiologic responses that may be beneficial for pain relief and/or useful to athletes as a passive form of warm-up.
57
Effect of l-menthol on laryngeal receptors.
TL;DR: It is concluded that l-menthol constitutes a specific stimulant of laryngeal cold receptors and could provide a useful tool for the study of their reflex effects.
54