Journal Article10.1111/J.2042-7158.1994.TB03871.X
Menthol and related cooling compounds.
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Identification of a cold receptor reveals a general role for TRP channels in thermosensation
TL;DR: These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
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Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
TL;DR: Ten new agonists and three antagonists of TRPM8 are identified and it is found that, in contrast to VR1,TRPM8 is inhibited rather than potentiated by protons.
Menthol: a natural analgesic compound
Nicoletta Galeotti,Lorenzo Di Cesare Mannelli,Gabriela Mazzanti,Alessandro Bartolini,Carla Ghelardini +4 more
TL;DR: Results indicate that (-)-menthol is endowed with analgesic properties mediated through a selective activation of kappa-opioid receptors.
401
The Epidemiology of Lung Cancer
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References
Menthol modulates oral sensations of warmth and cold
TL;DR: Aqueous solutions of menthol were found to affect oral thermal sensation in the following ways: When menthol solutions were sipped and held in the mouth for 5 sec, solutions above oral temperature felt significantly warmer than deionized water of the same temperature (warmth enhancement).
84
•Journal Article
Cellular and molecular mechanisms of bacterial adhesion to respiratory mucosa
TL;DR: Different bacterial species adhere avidly to respiratory mucus, and the first way in which most of the respiratory pathogens associate with the airway epithelium is likely to be by their adhesion to mucus.
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Calcium channel current inactivation is selectively modulated by menthol.
TL;DR: Results indicate a modulating action of menthol on Ca inactivation, which was studied in identified Helix neurons and indicated a sensitizing effect of ment hol on Ca-dependent inactivation.
77
The effect of local anaesthesia of the nasal vestibule on nasal sensation of airflow and nasal resistance
TL;DR: Neither injection of lignocaine or normal saline had any significant effect on nasal resistance to airflow as assessed by active anterior rhinomanometry.
73
Menthol inhibits the perception of warmth.
TL;DR: Although masking of sensations of warmth by menthol-induced sensations of cold is discussed as a possible explanation for the results, a direct effect of the menthol molecule on warm receptors (i.e., inhibition or desensitization) is considered a more likely explanation.
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