Membrane-protein interactions in mechanosensitive channels.

TL;DR: It is shown that charge neutralization can drive the shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB), which provides a platform for understanding the structure-function relationship of biological channels and designing rules for the shape control of DNA nanostructures in biomedical applications.

TL;DR: A coarse-grained model is used to explore the composite membrane-protein system and a simulation methodology based on thermodynamic integration is developed to examine free energy changes during membrane shape transitions.

Abstract: Physical Biology, pp. 217-246 (2008) No AccessBiology by the NumbersRob PhillipsRob PhillipsDepartment of Applied Physics, California Institute of Technology, Pasadena, CA 91125, CA, USAhttps://doi.org/10.1142/9781848162013_0010Cited by:1 (Source: Crossref) PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: Science was once called "natural philosophy" and had as its purview the scientific study of all of nature. Increasing specialization led to a splintering of natural philosophy into a number of separate disciplines and one of the outcomes of this trend was that physics emerged largely as the study of inanimate matter. This peculiar state of affairs imposed an unnatural barrier which largely prevented physicists from seeing the study of living matter as part of their core charter. Similarly, the style of analysis favored in the life sciences was often descriptive, isolating much of the biological mainstream from quantitative descriptions as the rule rather than the exception. An exciting outcome of the biological revolution of the last 50 years is that the study of living matter is emerging as a true interdisciplinary science that will enrich traditional physics and biology alike. I examine some of the philosophical underpinnings of physical biology and then illuminate these ideas through several case studies that highlight the interplay between quantitative data and the models set forth to greet them. One of the interesting outcomes of an analysis from the physical biology perspective is that topics that seem very distant biologically are next door neighbors in physical biology. FiguresReferencesRelatedDetailsCited By 1Cited by lists all citing articles based on Crossref citation.Pathogen-derived mechanical cues potentiate the spatio-temporal implementation of plant defenseOphélie Léger, Frédérick Garcia, Mehdi Khafif, Sebastien Carrere and Nathalie Leblanc-Fournier et al.27 December 2022 | BMC Biology, Vol. 20, No. 1 Recommended Physical Biology Metrics History PDF download

TL;DR: A theory of the elasticity of lipid bilayers is proposed and it is argued that in the case of vesicles (= closed bilayer films) the only elasticity controlling nonspherical shapes is that of curvature.

Abstract: ALMOST two generations have passed since the original publication of Timoshenko's Theory of Elasticity, and countless thousands of students and engineers have found great pleasure and stimulation from the rewarding insight into the elastic behavior of solid materials provided by the clarity and succinctness of its presentation. The only previous revision of the book, done in collaboration with Professor Goodier, was published just about 20 years ago and emphasized developments in thermal stress problems and elastic wave propagation. This third edition, prepared by Norman Goodier just before his passing last Fall, is a much more extensive revision of the basic work and yet retains all of the flavor and enduring qualities of the original. The present volume is almost a third larger than the first edition and has been completely reset and a number of figures have been redrawn. Timoshenko and Goodier's Theory of Elasticity has a new suit of clothes and is well prepared to meet and serve future generations. Specific revisions incorporated in this third edition are described briefly as follows. End effects and eigensolutions associated with Saint-Venant's principle are given in Chapters 3 and 4. Discontinuous displacements have been given more explicit treatment as edge and screw dislocations in several chaptersChapter 5 on photoelastic methods has been expanded to include the moire's method. The old chapter on strain-energy methods has been rewritten and incorporated into Chapter 8 (General Theorems) as a basis for the analysis of Thermal Stress (Chapter 13). The presentation of complex potentials for two-dimensional problems has been considerably expanded to include the methods attributed to Muskhelishvili. The chapters on Thermal Stress (Chapter 13) and Wave Propagation (Chapter 14) have again been almost completely rewritten in order to emphasize more recent developments. Many other sections have been revised to a greater or lesser extent to provide for more simplified and/or more coheren t treatments.

TL;DR: The Motility Models: From Crossbridges to Motion chapter describes the building blocks of the Cytoskeleton and some of the mechanisms used in its manufacture are described.

TL;DR: To test this hypothesis, peak-to-peak headgroup thicknesses h(pp) of bilayers were obtained from x-ray diffraction of multibilayer arrays at controlled relative humidities and showed that poly-cis unsaturated chain bilayers are thinner and more flexible than saturated/monounsaturated chain Bilayers.