MEF-2 isoforms' (A-D) roles in development and tumorigenesis.
Kiran Madugula,Ria Mulherkar,Zafar K. Khan,DeGaulle I. Chigbu,Dip Patel,Edward W. Harhaj,Pooja Jain +6 more
TL;DR: This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.
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Abstract: Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.
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Citations
p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin-dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression
Qing Xu,Ching Fung Cheung,Lanying Liu,Xue Li,Siu-Pok Yee,Xiang-Jiao Yang,Zhenguo Wu +6 more
- 01 Jan 2001
TL;DR: In this paper, the authors identify myogenin as an important transcriptional target under the control of three intracellular signaling pathways, namely, the p38 mitogen-activated protein kinase- (MAPK), calcium-calmodulin-dependent protein Kinase (CaMK), and calcineurin-mediated pathways, during skeletal muscle differentiation.
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•Journal Article
IS012 MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression
TL;DR: It is demonstrated that the SMHC promoter region (−1594 to −1462 base pairs) containing the A/T-rich element can activate the heterologous thymidine kinase promoter in smooth muscle cells, but not in fibroblasts.
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Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors
TL;DR: This review introduces an important enzyme family HDAC, a key regulator in histone deacetylation, and presents the latest progress of HDAC inhibitors (HDACi), as a potential treatment target in cardiac hypertrophy.
Progress on the roles of MEF2C in neuropsychiatric diseases
Zhikun Zhang,Yongxiang Zhao +1 more
TL;DR: The relationship between MEF2C and neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer's disease (AD), is discussed in this article .
Iconography : HDACis (class I), cancer stem cell, and phytochemicals: Cancer therapy and prevention implications
Sahar Bayat,Mahmoud Shekari Khaniani,Jalal Choupani,Mohammad R. Alivand,Sima Mansoori Derakhshan +4 more
- 31 Dec 2017
TL;DR: A perspective concerning HDAC-targeted phytochemicals to control CSC in tumors is presented and it is believed that controlling CSC via epigenetic reprogramming such as targeting HDACs could be helpful in regulating the acetylation pattern of chromatin.
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References
A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation
Aryaman Shalizi,Brice Gaudilliere,Zengqiang Yuan,Judith Stegmüller,Takahiro Shirogane,Qingyuan Ge,Yi Tan,Brenda A. Schulman,J. Wade Harper,Azad Bonni +9 more
TL;DR: A requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex is reported.
Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer
TL;DR: This review describes potential applications of chimeric HDAC inhibitors, which simultaneously modulate not only HDAC but also multiple targets, in treatment of relapsing and drug‐resistant cancers.
MEF2C and CEBPA: Possible co-regulators in chronic myeloid leukemia disease progression
TL;DR: Imatinib, the drug of choice for CML, abrogates MEF2C expression and reverses CEBPA repression both in the cell line and the primary cells, and it is reported that the existence of a MEBPA correlation in CML disease progression is reported.
Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization.
Li Zhang,Yang Sun,Mingjian Fei,Cheng Tan,Jing Wu,Jie Zheng,Jiqing Tang,Wei Sun,Zhaoliang Lv,Jiandong Bao,Qiang Xu,Huixin Yu +11 more
TL;DR: It is reported for the first time that MEF2A is physiologically degraded through the CMA pathway, and oxidative stress-induced lysosome destabilization leads to the disruption of MEf2A degradation as well as the dysregulation of its function.
Rotenone Upregulates Alpha-Synuclein and Myocyte Enhancer Factor 2D Independently from Lysosomal Degradation Inhibition
Gessica Sala,A Arosio,G Stefanoni,Laura Melchionda,Chiara Riva,D Marinig,Laura Brighina,Carlo Ferrarese +7 more
TL;DR: This study explored the effect of mitochondrial complex I inhibitor rotenone on CMA substrates, alpha-synuclein and MEF2D, and effectors, lamp2A and hsc70, in a human dopaminergic neuroblastoma SH-SY5Y cell line to highlight that roten one affects alpha- synucleinand MEF 2D protein levels through a mechanism independent from lysosomal degradation inhibition.