MEF-2 isoforms' (A-D) roles in development and tumorigenesis.
Kiran Madugula,Ria Mulherkar,Zafar K. Khan,DeGaulle I. Chigbu,Dip Patel,Edward W. Harhaj,Pooja Jain +6 more
TL;DR: This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.
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Abstract: Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.
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Citations
p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin-dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression
Qing Xu,Ching Fung Cheung,Lanying Liu,Xue Li,Siu-Pok Yee,Xiang-Jiao Yang,Zhenguo Wu +6 more
- 01 Jan 2001
TL;DR: In this paper, the authors identify myogenin as an important transcriptional target under the control of three intracellular signaling pathways, namely, the p38 mitogen-activated protein kinase- (MAPK), calcium-calmodulin-dependent protein Kinase (CaMK), and calcineurin-mediated pathways, during skeletal muscle differentiation.
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•Journal Article
IS012 MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression
TL;DR: It is demonstrated that the SMHC promoter region (−1594 to −1462 base pairs) containing the A/T-rich element can activate the heterologous thymidine kinase promoter in smooth muscle cells, but not in fibroblasts.
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Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors
TL;DR: This review introduces an important enzyme family HDAC, a key regulator in histone deacetylation, and presents the latest progress of HDAC inhibitors (HDACi), as a potential treatment target in cardiac hypertrophy.
Progress on the roles of MEF2C in neuropsychiatric diseases
Zhikun Zhang,Yongxiang Zhao +1 more
TL;DR: The relationship between MEF2C and neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer's disease (AD), is discussed in this article .
Iconography : HDACis (class I), cancer stem cell, and phytochemicals: Cancer therapy and prevention implications
Sahar Bayat,Mahmoud Shekari Khaniani,Jalal Choupani,Mohammad R. Alivand,Sima Mansoori Derakhshan +4 more
- 31 Dec 2017
TL;DR: A perspective concerning HDAC-targeted phytochemicals to control CSC in tumors is presented and it is believed that controlling CSC via epigenetic reprogramming such as targeting HDACs could be helpful in regulating the acetylation pattern of chromatin.
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References
Mef2 is Regulated by CaMKIIδ2 and a HDAC4/HDAC5 Heterodimer in Vascular Smooth Muscle Cells
TL;DR: A mechanism by which CaMKIIδ(2) mediates MEF2-dependent gene transcription in VSMCs through regulation of HDAC4 and HDAC5 is illustrated.
Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle.
TL;DR: The aim of this study is to determine whether Cpt1b expression is regulated by MEF2 in response to exercise training.
miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D
TL;DR: The level of myocyte enhancer factor 2D (MEF2D), a key regulatory protein for cardiac development, was elevated in specimens of cardiac myxoma, and was positively associated with the proliferation ofMyxoma cells.
MEF2C and EBF1 Co-regulate B Cell-Specific Transcription.
TL;DR: This study elucidates both activation and repression mechanisms, identifies regulatory partners, and downstream targets by which MEF2C regulates lymphoid-specific differentiation, and identified early B cell factor-1 (EBF1) as a co-regulator of gene expression with MEf2C.
Contribution of Myocyte Enhancer Factor 2 Family Transcription Factors to BZLF1 Expression in Epstein-Barr Virus Reactivation from Latency
TL;DR: Interestingly, the MEF2 mutant EBV featured relatively high repressive histone methylation, such as H3K27me3, but CpG DNA methylation levels were comparable around Zp and the BRLF1 promoter (Rp), which shed light on BZLF1 expression and EBV reactivation from latency.