Book Chapter10.1017/9781316492376.014
Medication-Resistant Epilepsy in Adults
Martin Holtkamp,Felix Benninger +1 more
- 31 Aug 2020
- pp 158-170
8
About: The article was published on 31 Aug 2020.
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Citations
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Targeted Treatment of Migrating Partial Seizures of Infancy with Quinidine (I6-2B)
TL;DR: The cardiac anti-arrhythmic drug quinidine is a partial antagonist of KCNT1, making it a candidate drug for treatment of Migrating Partial Seizure of Infant (MPSI) as mentioned in this paper.
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Progressive Hippocampal And Extrahippocampal Atrophy In Drug Resistant Epilepsy
TL;DR: Experimental data indicate that epileptogenesis in developing brain may not require significant neuronal loss, which is in keeping with clinical observations that progressive cognitive and behavioural impairment may occur in patients with no detectable brain atrophy.
121
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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu,Seong A. Kang,Jonathan Rameseder,Yi Zhang,Kathleen Ottina,Daniel Lim,Timothy R. Peterson,Yongmun Choi,Nathanael S. Gray,Michael B. Yaffe,Jarrod A. Marto,David M. Sabatini +11 more
TL;DR: In this paper, the mTOR-regulated phosphoproteome was defined by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using positional scanning peptide libraries.
47
Clinical and video-polygraphic features of epileptic spasms in adults with corticl migration disorders
TL;DR: Ictal polygraphic studies showed a positive, diffuse, high amplitude slow wave activity during spasms, with superimposed fast activity, followed by a diffuse flattening in all cases with a typical muscle pattern.
38
References
Retrospective audit of postictal generalized EEG suppression in telemetry
TL;DR: In this article, the authors retrospectively audited frequency and electroclinical features of this pattern as well as immediate management following tonic-clonic seizures during telemetry and found that those with PI EEG suppression were significantly more likely to be motionless after the seizure and have simple nursing interventions performed (suction, oxygen administration, placed in recovery position, vital signs checked) This pattern is relatively common and requires further study as a potential marker for increased mortality in epilepsy.
Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus
TL;DR: Findings demonstrate that the regulation of surface-expressed GABAR pool during SE is subunit-specific and occurs independent of ligand binding.
Megalencephaly-capillary malformation (MCAP) and megalencephaly-polydactyly-polymicrogyria-hydrocephalus (MPPH) syndromes: two closely related disorders of brain overgrowth and abnormal brain and body morphogenesis.
Ghayda M. Mirzaa,Robert L. Conway,Karen W. Gripp,Tally Lerman-Sagie,Dawn H. Siegel,Linda S. deVries,Dorit Lev,Nancy Kramer,Elizabeth Hopkins,John M. Graham,William B. Dobyns +10 more
TL;DR: Comparing the features in 42 patients evaluated for physical and neuroimaging characteristics of MCAP and MPPH and proposing a more global view of these syndromes based on classes of developmental abnormalities, it is proposed that MCAP diagnostic criteria include progressive MEG with either vascular anomalies or syndactyly.
Minimally Invasive Neurosurgery for Epilepsy Using Stereotactic MRI Guidance
TL;DR: Multiple minimally invasive, image-guided techniques have been applied to the treatment of epilepsy and these techniques can be divided into thermoablative and disconnective techniques, each of which has been described only in small case series.
Postictal generalized electroencephalographic suppression is associated with generalized seizures
Rainer Surges,Adam Strzelczyk,Adam Strzelczyk,Catherine Scott,Matthew C. Walker,Josemir W. Sander +5 more
TL;DR: It is concluded that PGES is facilitated by secondarily GTCS, but does not seem to be an independent risk factor for SUDEP.
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