Medication-Resistant Epilepsy in Adults

TL;DR: Experimental data indicate that epileptogenesis in developing brain may not require significant neuronal loss, which is in keeping with clinical observations that progressive cognitive and behavioural impairment may occur in patients with no detectable brain atrophy.

TL;DR: In this paper, the mTOR-regulated phosphoproteome was defined by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using positional scanning peptide libraries.

TL;DR: Ictal polygraphic studies showed a positive, diffuse, high amplitude slow wave activity during spasms, with superimposed fast activity, followed by a diffuse flattening in all cases with a typical muscle pattern.

TL;DR: Cases of alleged vaccine encephalopathy could in fact be a genetically determined epileptic encephalopathies that arose de novo and, if confirmed in other cohorts, major societal implications for the general acceptance of vaccination.

TL;DR: This work investigated the association between the risk of suicide in persons with epilepsy and clinical factors that might increase or have been suggested to increase therisk of suicide.

TL;DR: Based on an appreciation of these four features in optimized images, hippocampal sclerosis can be diagnosed with a high degree of accuracy and sensitivity.

TL;DR: This study investigates whether referrals for epilepsy surgery evaluation are underutilized, and whether this treatment can cure patients with intractable epilepsy.