Book Chapter10.1017/9781316492376.014
Medication-Resistant Epilepsy in Adults
Martin Holtkamp,Felix Benninger +1 more
- 31 Aug 2020
- pp 158-170
8
About: The article was published on 31 Aug 2020.
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Progressive Hippocampal And Extrahippocampal Atrophy In Drug Resistant Epilepsy
TL;DR: Experimental data indicate that epileptogenesis in developing brain may not require significant neuronal loss, which is in keeping with clinical observations that progressive cognitive and behavioural impairment may occur in patients with no detectable brain atrophy.
121
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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu,Seong A. Kang,Jonathan Rameseder,Yi Zhang,Kathleen Ottina,Daniel Lim,Timothy R. Peterson,Yongmun Choi,Nathanael S. Gray,Michael B. Yaffe,Jarrod A. Marto,David M. Sabatini +11 more
TL;DR: In this paper, the mTOR-regulated phosphoproteome was defined by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using positional scanning peptide libraries.
47
Clinical and video-polygraphic features of epileptic spasms in adults with corticl migration disorders
TL;DR: Ictal polygraphic studies showed a positive, diffuse, high amplitude slow wave activity during spasms, with superimposed fast activity, followed by a diffuse flattening in all cases with a typical muscle pattern.
38
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Rahul Manchanda,B Schaefer,Richard S. McLachlan,Warren T. Blume,Samuel Wiebe,John P. Girvin,A Parrent,P. A. Derry +7 more
TL;DR: An analysis of the prevalence and pattern of psychiatric morbidity among 300 consecutive epileptic patients refractive to treatment and admitted during a six year period for evaluation of their candidature for surgery found no significant findings between the different seizure focus groups on the neurotic subscores.
Seizure reporting technologies for epilepsy treatment: A review of clinical information needs and supporting technologies.
Jonathan Bidwell,Thanin Khuwatsamrit,Brittain Askew,Joshua Andrew Ehrenberg,Sandra L. Helmers +4 more
TL;DR: Inertial seizure detection devices coupled with video capture for recording seizures at night could stand to address collecting seizure counts that are more accurate than current patient self-reporting during day and night time use.
Uncontrolled epilepsy is not necessarily the same as drug-resistant epilepsy: Differences between populations with newly diagnosed epilepsy and chronic epilepsy
Xiaoting Hao,Danielle Goldberg,Kevin Kelly,Linda J. Stephen,Patrick Kwan,Patrick Kwan,Martin J. Brodie +6 more
TL;DR: Efforts should be made to understand why a patient is not seizure-free so that appropriate adjustment in AED regimen can be taken to enable the patient to attain long-term seizure freedom.
The histopathology of polymicrogyria: a series of 71 brain autopsy studies.
Anna Jansen,Yves Robitaille,Mrinalini Honavar,Nandini Mullatti,Richard J. Leventer,Eva Andermann,Frederick Andermann,Waney Squier +7 more
TL;DR: Polymicrogyria is one of the most common forms of cortical malformation yet the mechanism of its development remains unknown, and the histopathological aspects in a large series including a significant proportion of fetal cases are described.
Mutations in α- and β-tubulin encoding genes: implications in brain malformations.
TL;DR: The present review, describing the structural and functional features of tubulin genes, aims to revise the main cerebral associated malformations and related clinical aspects, suggesting a genotype-phenotype correlation.
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