Medication-Resistant Epilepsy in Adults

TL;DR: Experimental data indicate that epileptogenesis in developing brain may not require significant neuronal loss, which is in keeping with clinical observations that progressive cognitive and behavioural impairment may occur in patients with no detectable brain atrophy.

TL;DR: In this paper, the mTOR-regulated phosphoproteome was defined by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using positional scanning peptide libraries.

TL;DR: Ictal polygraphic studies showed a positive, diffuse, high amplitude slow wave activity during spasms, with superimposed fast activity, followed by a diffuse flattening in all cases with a typical muscle pattern.

TL;DR: An infant who had successful epilepsy surgery for intractable infantile spasms in the setting of bilateral periventricular leukomalacia and remote germinal matrix hemorrhage is reported, one of very few reported cases strongly implicating acquired focal cortical dysplasia in response to a prenatal insult.

TL;DR: Medications that inhibit mTOR are being used to treat TSC-related tumors, and current studies are investigating whether these agents could alleviate other TSC complications.

TL;DR: A now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen is described.

TL;DR: The authors used the definition of the Lennox-Gastaut syndrome (LGS) adopted by the Commission on Classification and Terminology of the International League against Epilepsy to describe patients with childhood LGS, finding that there was a different prognosis between those with an onset between the ages of 13 and 15, where the entire syndrome persisted and the evolution is for the worse, and those with a onset after the age of 15,Where the outcome was better.