Mechanisms That Regulate the Function of the Selectins and Their Ligands

TL;DR: It is demonstrated that EHV-1 infection induces adhesion of CD172a+ cells to EC, which enhances viral replication, but that transfer of viral material from CD 172a+ Cells to EC is a very specific and rare event.

TL;DR: This review will focus on highlighting the mechanisms that leukocytes exploit to open cellular junctions and how these junctions must not be destroyed during transmigration.

TL;DR: The hypothesis that cocaine enhances inflammatory cell infiltration via catecholamine-induced upregulation of cell adhesion molecule (CAM) expression in adult BALB/c mouse hearts is examined to suggest that cocaine-induced neutrophil infiltration is mediated by beta-adrenergic stimulation through up regulation of CAM expression, which enhances PMN adhesion.

TL;DR: Methods for their preparation from monosaccharidic precursors by direct C-glycosylation, dipolar cycloaddition or Larock cyclization are described.

TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.

TL;DR: Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1.

TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.