Journal Article10.1152/PHYSREV.1999.79.1.181
Mechanisms That Regulate the Function of the Selectins and Their Ligands
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TL;DR: Convincing data have been published supporting the idea that selectins and glycoprotein ligands of the selectins participate in the activation of leukocyte integrins.
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Abstract: Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999. — Selectins are a family of three cell adhesion m...
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Citations
A mouse model to assess endothelial activation in vivo by targeted insertion of alkaline phosphatase into the E-selectin gene
Marcel Luyten,Matthias Hofmann,Edgar Käslin,Bernd Klanke,Charles Pally,Ryosei Kawai,Hans-Günter Zerwes +6 more
TL;DR: The model described here allows monitoring of the E‐selectin expression in vivo, offering a noninvasive means to quantitate inflammatory endothelial cell activation and to evaluate therapeutic approaches designed to inhibit endothelium cell activation.
Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.
Michael Pierre Bernimoulin,Xian Lu Zeng,Claire Abbal,Sylvain Giraud,Manuel Martinez,Olivier Michielin,Marc Schapira,Olivier Spertini +7 more
TL;DR: The effect of post-translational modifications of PSGL-1 including Tyr sulfation and presentation of sialylated and fucosylated O-glycans for L-selectin binding is examined to pinpoint the structural characteristics of PS GL-1 that are required for optimal interactions with L- selectin and may be responsible for the specific kinetic and mechanical bond properties of the L- Selectin-PSGL- 1 adhesion receptor-counterreceptor pair.
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