Mechanisms That Regulate the Function of the Selectins and Their Ligands

TL;DR: It is demonstrated that B16F10 melanoma cells activate the enzyme acid sphingomyelinase in thrombocytes via the surface molecule P-selectin, by which ceramide is released, which indicates that tumor metastasis can be blocked pharmacologically, which is of great clinical interest.

TL;DR: A novel pathway in epithelial ovarian tumorigenesis is identified (PI3K PKCiota Cyclin E anchorage-independent growth), which could potentially be targeted therapeutically.

TL;DR: In this article, the authors show that T. cruzi upregulates E-selectins in cardiac ECs to which it binds in a ligand-receptor fashion, whether under static or shear flow conditions.

TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.

TL;DR: Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1.

TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.