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Mechanisms of Egg Activation
Richard Nuccitelli,Gary N. Cherr,Wallis H. Clark +2 more
- 15 Apr 2013
75
TL;DR: Research over the past decade has yielded several breakthroughs in this field and most of them are discussed in this volume, including: electrical events accompanying sperm-egg interactions; signal transduction mechanisms in egg activation; metabolic co-activation.
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Abstract: Proceedings of the meeting held in Sept. 1988. Research over the past decade has yielded several breakthroughs in this field and most of them are discussed in this volume, including: electrical events accompanying sperm-egg interactions; signal transduction mechanisms in egg activation; metabolic co
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Citations
Comparative Biology of Calcium Signaling during Fertilization and Egg Activation in Animals
TL;DR: Findings fail to support the dichotomy in calcium signaling modes that had previously been proposed for protostomes vs deuterostomes and instead suggest that various features of fertilization-induced calcium signals are widely shared throughout the animal kingdom.
742
cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis.
Antony Galione,Alison M. White,Nicholas J. Willmott,Michelle Turner,Barry V. L. Potter,Stephen P. Watson +5 more
TL;DR: A novel action of 3',5'-cyclic guanosine monophosphate (cGMP) is demonstrated in stimulating the synthesis of cADPR from β-NAD+ by activating its synthetic enzyme ADP-ribosyl cyclase911 in sea urchin eggs and egg homogenates.
355
Molecular basis of mammalian egg activation.
TL;DR: This information provides a framework within which to examine known and proposed signaling mechanisms that regulate egg activation, helps understand the role of several possible second messengers in eggactivation, and helps describe the sperm–egg interaction that may result in the production of second Messengers.
271
Membranes, ions, and impulses: Dedication to Kacy Cole
John W. Moore
- 01 Apr 1975
TL;DR: This collection of papers given at the Colloquium on Membranes, Ions, and Impulses is dedicated to Kacy Cole and Dan Tosteson, the American Physiological Society President for 1974.
133
How do sperm activate eggs
TL;DR: This chapter provides an overview of the recent evidence for involvement of the inositol cycle and G-proteins in egg activation and also thoughts and hypotheses on egg activation mechanisms.
102
References
Hormone-induced loss of surface membrane during maturation of starfish oocytes: differential effects on potassium and calcium channels.
TL;DR: Using voltage-clamp and ultrastructural techniques to study maturation in starfish, a novel process by which 1-MA alters the electrical properties of the oocyte is discovered, which results in a larger and more rapidly rising action potential in the mature egg, which may aid in the fast block to polyspermy.
57
Changes in intracellular acidic compartments in sea urchin eggs after activation
Hon Cheung Lee,David Epel +1 more
TL;DR: The results indicate that the internal pH rises after egg activation triggers the acidification of these granules, suggesting their possible functions, as in intracellular pH regulation, are discussed.
56
Intracellular Ca2+ requirement for activation of the Na+/H+ exchanger in vascular smooth muscle cells
T Mitsuhashi,Harlan E. Ives +1 more
TL;DR: Altered [Ca2+]i does not itself affect Na+/H+ exchange activity in vascular smooth muscle but instead modulates activation of the transporter by particular stimuli.
55
Human spleen histone H2B. Isolation and amino acid sequence.
TL;DR: In this paper, the amino acid sequences of human histones have been investigated for studies of histone evolution, and the whole histone was prepared from human spleen and was separated into 3 fractions, H4+H3+H2A, H2B, and H1, by using CM-cellulose chromatography.
53
Inhibition of denuded mouse oocyte meiotic maturation by tumor-promoting phorbol esters and its reversal by retinoids.
TL;DR: A role for calcium and/or phospholipids in the regulation of meiotic maturation is suggested and it is suggested that forskolin and phorbol esters mediate their effects through different pathways.
53