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Mechanisms of Egg Activation
Richard Nuccitelli,Gary N. Cherr,Wallis H. Clark +2 more
- 15 Apr 2013
75
TL;DR: Research over the past decade has yielded several breakthroughs in this field and most of them are discussed in this volume, including: electrical events accompanying sperm-egg interactions; signal transduction mechanisms in egg activation; metabolic co-activation.
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Abstract: Proceedings of the meeting held in Sept. 1988. Research over the past decade has yielded several breakthroughs in this field and most of them are discussed in this volume, including: electrical events accompanying sperm-egg interactions; signal transduction mechanisms in egg activation; metabolic co
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Citations
Comparative Biology of Calcium Signaling during Fertilization and Egg Activation in Animals
TL;DR: Findings fail to support the dichotomy in calcium signaling modes that had previously been proposed for protostomes vs deuterostomes and instead suggest that various features of fertilization-induced calcium signals are widely shared throughout the animal kingdom.
742
cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis.
Antony Galione,Alison M. White,Nicholas J. Willmott,Michelle Turner,Barry V. L. Potter,Stephen P. Watson +5 more
TL;DR: A novel action of 3',5'-cyclic guanosine monophosphate (cGMP) is demonstrated in stimulating the synthesis of cADPR from β-NAD+ by activating its synthetic enzyme ADP-ribosyl cyclase911 in sea urchin eggs and egg homogenates.
355
Molecular basis of mammalian egg activation.
TL;DR: This information provides a framework within which to examine known and proposed signaling mechanisms that regulate egg activation, helps understand the role of several possible second messengers in eggactivation, and helps describe the sperm–egg interaction that may result in the production of second Messengers.
271
Membranes, ions, and impulses: Dedication to Kacy Cole
John W. Moore
- 01 Apr 1975
TL;DR: This collection of papers given at the Colloquium on Membranes, Ions, and Impulses is dedicated to Kacy Cole and Dan Tosteson, the American Physiological Society President for 1974.
133
How do sperm activate eggs
TL;DR: This chapter provides an overview of the recent evidence for involvement of the inositol cycle and G-proteins in egg activation and also thoughts and hypotheses on egg activation mechanisms.
102
References
Calcium-dependent exocytosis in an in vitro secretory granule plasma membrane preparation from sea urchin eggs and the effects of some inhibitors of cytoskeletal function.
TL;DR: Evidence is presented that demonstrates that, when the cytoplasmic face of the egg plasma membrane is exposed to micromolar calcium concentrations, an exocytosis of the cortical granules occurs which corresponds to the cortex granule exocyTosis seen when the egg is fertilized.
89
Voltage clamp studies of fertilization in sea urchin eggs: I. Effect of clamped membrane potential on sperm entry, activation, and development
John W. Lynn,Edward L. Chambers +1 more
TL;DR: Present evidence suggests an effect of the electrical field across the plasma membrane in suppressing sperm entry in the sea urchin egg, and monospermic voltage clamped eggs that cleave develop to normal swimming blastulae.
86
Induction of meiotic maturation in Xenopus oocytes by 12-O-tetradecanoylphorbol 13-acetate
Bradley J. Stith,James L. Maller +1 more
TL;DR: Results indicate that protein kinase C is capable of regulating oocyte maturation in Xenopus, and reversibly inhibited insulin- but not progesterone-induced maturation.
86
A change in permeability and uptake of [14C]uridine in response to fertilization in Strongylocentrotus purpuratus eggs.
TL;DR: The observations are believed to indicate that fertilized eggs accumulate uridine by phosphorylating the nucleoside at the surface of the cell, a process which may be deficient in unfertilized eggs because of lack of phosphate donors or of the necessary enzymes.
81
Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes.
TL;DR: Results suggest the involvement of a pertussis sensitive G-protein in the pathway coupling 1-methyladenine action at the cell surface to the reinitiation of meiosis.
80