Mechanical stress-induced autophagic response: A cancer-enabling characteristic?

TL;DR: In this paper, the authors highlight the role of physical forces in autophagy regulation and their potential implications in both physiological as well as pathological conditions, and stimulate novel questions to further the investigation of the mechanical requirements of autophagation and appreciate the extent to which mechanical signals affect this process.

TL;DR: In this article , the authors introduce the potential of targeting the mechanical program while also providing its challenges and shortcomings as a strategy for cancer treatment, as well as provide its benefits and drawbacks.

TL;DR: This review summarizes the evidence in the literature supporting pro- and anti-tumorigenic and -therapeutic roles of autophagy in cancer, and expands on the emerging role of genetically-engineered mouse models of cancer in shedding light on these issues in vivo.

TL;DR: In this article , the authors studied the remodeling of homogeneous tumors, at their early stage of growth, in the context of continuum mechanics, and developed an evolution law for the tumor-associated deformation.

TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.

TL;DR: Here, the cellular processes influenced by long ncRNAs to the hallmarks of cancer are linked and therefore, an ncRNA point-of-view on tumor biology is provided.

TL;DR: It is suggested that metastasis can be portrayed as a two-phase process: the first phase involves the physical translocation of a cancer cell to a distant organ, whereas the second encompasses the ability of the cancer cellto develop into a metastatic lesion at that distant site.

TL;DR: The functional relationship between apoptosis and autophagy is complex in the sense that, under certain circumstances,autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway.